The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagai, Y.
Right arrow Articles by Miyake, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagai, Y.
Right arrow Articles by Miyake, K.
The Journal of Immunology, 2005, 174: 7043-7049.
Copyright © 2005 by The American Association of Immunologists

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes1

Yoshinori Nagai2,3,*, Toshihiko Kobayashi2,*, Yuji Motoi*, Kohtaroh Ishiguro*, Sachiko Akashi*, Shin-ichiroh Saitoh*, Yutaka Kusumoto*, Tsuneyasu Kaisho{ddagger},§, Shizuo Akira{ddagger}, Mitsuru Matsumoto, Kiyoshi Takatsu{dagger} and Kensuke Miyake4,||,*

Divisions of* Infectious Genetics and {dagger} Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; {ddagger} Department of Host Defense, Research Institute for Microbial Diseases, Osaka University; § The Institute of Physical and Chemical Research (Japan), Research Center for Allergy and Immunology, Kanagawa, Japan; Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima; || Core Research for Engineering, Science, and Technology, Japan Science and Technology Corporation, Tokyo, Japan

Low-affinity IgG3 Abs to microbial membranes are important for primary immune defense against microbes, but little is known about the importance of TLRs in their production. IgG3 levels were extremely low in mice lacking radioprotective 105 (RP105), a B cell surface molecule structurally related to TLRs. RP105–/– B cells proliferated poorly in response to not only the TLR4 ligand LPS but also TLR2 ligand lipoproteins, both of which mediate the immunostimulatory activity of microbial membranes. RP105–/– mice were severely impaired in hapten-specific Ab production against LPS or lipoproteins. CD138 (syndecan-1)-positive plasma cells were detected after lipid A injection in wild-type spleen but much less in RP105–/– spleen. RP105 ligation in vivo induced plasma cell differentiation. RP105 expression was ~3-fold higher on marginal zone B cells than on follicular and B1 cells and was down-regulated on germinal center cells. These results demonstrate that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes.




This article has been cited by other articles:


Home page
 Int ImmunolHome page
T. Kobayashi, K. Takahashi, Y. Nagai, T. Shibata, M. Otani, S. Izui, S. Akira, Y. Gotoh, H. Kiyono, and K. Miyake
Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice
Int. Immunol., July 1, 2008; 20(7): 881 - 891.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
K. Takahashi, T. Shibata, S. Akashi-Takamura, T. Kiyokawa, Y. Wakabayashi, N. Tanimura, T. Kobayashi, F. Matsumoto, R. Fukui, T. Kouro, et al.
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
J. Exp. Med., November 26, 2007; 204(12): 2963 - 2976.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Divanovic, A. Trompette, L. K. Petiniot, J. L. Allen, L. M. Flick, Y. Belkaid, R. Madan, J. J. Haky, and C. L. Karp
Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105
J. Leukoc. Biol., August 1, 2007; 82(2): 265 - 271.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. A. Fairfax, L. M. Corcoran, C. Pridans, N. D. Huntington, A. Kallies, S. L. Nutt, and D. M. Tarlinton
Different Kinetics of Blimp-1 Induction in B Cell Subsets Revealed by Reporter Gene
J. Immunol., April 1, 2007; 178(7): 4104 - 4111.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. R. Alugupalli, S. Akira, E. Lien, and J. M. Leong
MyD88- and Bruton's Tyrosine Kinase-Mediated Signals Are Essential for T Cell-Independent Pathogen-Specific IgM Responses
J. Immunol., March 15, 2007; 178(6): 3740 - 3749.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
S. Okamoto, Y. Terao, H. Kaminishi, S. Hamada, and S. Kawabata
Inflammatory Immune Responses by Water-insoluble {alpha}-glucans
J. Dent. Res., March 1, 2007; 86(3): 242 - 248.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. E. Gunn and J. W. Brewer
Evidence That Marginal Zone B Cells Possess an Enhanced Secretory Apparatus and Exhibit Superior Secretory Activity
J. Immunol., September 15, 2006; 177(6): 3791 - 3798.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. David, C. L. Cochrane, S. K. Duncan, and J. W. Schrader
Pure Lipopolysaccharide or Synthetic Lipid A Induces Activation of p21Ras in Primary Macrophages through a Pathway Dependent on Src Family Kinases and PI3K
J. Immunol., December 15, 2005; 175(12): 8236 - 8241.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
S. Divanovic, A. Trompette, S. F. Atabani, R. Madan, D. T. Golenbock, A. Visintin, R. W. Finberg, A. Tarakhovsky, S. N. Vogel, Y. Belkaid, et al.
Inhibition of TLR-4/MD-2 signaling by RP105/MD-1
Innate Immunity, December 1, 2005; 11(6): 363 - 368.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.