HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Beauregard, C. Articles by Niederkorn, J. Y. Search for Related Content PubMed PubMed Citation Articles by Beauregard, C. Articles by Niederkorn, J. Y.

Cutting Edge: Atopy Promotes Th2 Responses to Alloantigens and Increases the Incidence and Tempo of Corneal Allograft Rejection¹

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390

A large body of evidence suggests that corneal allograft rejection is mediated by a type 1 Th cell response and that deviation toward type 2 immunity favors graft survival. However, clinical observations indicate that patients with severe ocular allergies have increased risk of corneal allograft rejection. We used a mouse model of atopic conjunctivitis to evaluate the effects of Th2 immune deviation on corneal allograft survival and possible mechanisms of graft rejection. Our results reveal the following novel findings: 1) atopic conjunctivitis promotes systemic Th2 immune responses to corneal graft donor alloantigens; 2) corneal allografts in atopic host eyes have an increased incidence and swifter tempo of rejection; 3) increased rejection is associated with alterations in systemic T cell-mediated responses to donor alloantigens; and 4) corneal allograft rejection in atopic hosts does not require the direct involvement of infiltrating eosinophils.

This article has been cited by other articles:

				J. Y. Niederkorn, P. W. Chen, J. Mellon, C. Stevens, and E. Mayhew Allergic Conjunctivitis Exacerbates Corneal Allograft Rejection by Activating Th1 and Th2 Alloimmune Responses J. Immunol., June 1, 2010; 184(11): 6076 - 6083. [Abstract] [Full Text] [PDF]

				T. Hayashi, S. Yamagami, K. Tanaka, S. Yokoo, T. Usui, S. Amano, and N. Mizuki Immunologic Mechanisms of Corneal Allografts Reconstituted from Cultured Allogeneic Endothelial Cells in an Immune-Privileged Site Invest. Ophthalmol. Vis. Sci., July 1, 2009; 50(7): 3151 - 3158. [Abstract] [Full Text] [PDF]

				J. Yamada, J. Hamuro, A. Fukushima, T. Ohteki, K. Terai, Y. Iwakura, H. Yagita, and S. Kinoshita MHC-Matched Corneal Allograft Rejection in an IFN-{gamma}/IL-17-Independent Manner in C57BL/6 Mice Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2139 - 2146. [Abstract] [Full Text] [PDF]

				T. H. Flynn, M. Ohbayashi, Y. Ikeda, S. J. Ono, and D. F. Larkin Effect of Allergic Conjunctival Inflammation on the Allogeneic Response to Donor Cornea Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4044 - 4049. [Abstract] [Full Text] [PDF]

				M. P. Keane, B. N. Gomperts, S. Weigt, Y. Y. Xue, M. D. Burdick, H. Nakamura, D. A. Zisman, A. Ardehali, R. Saggar, J. P. Lynch III, et al. IL-13 Is Pivotal in the Fibro-Obliterative Process of Bronchiolitis Obliterans Syndrome J. Immunol., January 1, 2007; 178(1): 511 - 519. [Abstract] [Full Text] [PDF]