| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Chain for FcR Is Associated with Reduced Production of IL-10 and TGF-
by Parasitized Cells 1
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104
Previous studies have shown that the in vitro ligation of Fc
Rs with IgG-opsonized Leishmania amastigotes promotes IL-10 production by macrophages. In addition, infection of either BALB/c mice lacking the common -chain of Fc receptors (FcR–/–) or mice genetically altered to lack circulating Ab (JHD) with Leishmania pifanoi results in reduced and delayed lesion development and a deficit in the recruitment of inflammatory cells into infected lesions. We show in this study that FcR–/– mice can control infection with Leishmania major and totally resolve cutaneous lesions. The ability to eventually control infection is not associated with a reduction in lesion inflammation or a reduction in the ability of Leishmania to parasitize cells through week 6 of infection. The immune response in healing FcR–/– mice is associated with a reduction in numbers of cells producing Th2-type cytokines, including IL-4 and IL-10, but not an increase in numbers of IFN--producing cells characteristic of a dominant Th1-type response. Instead, we observe a reduction in levels of IL-10 and TGF-
within infected lesions, including reduced levels of these cytokines within parasitized macrophages. Together, these results suggest that uptake of opsonized parasites via FcRs may be a strong in vivo stimulus for the production of anti-inflammatory cytokines that play a role in susceptibility to infection.
This article has been cited by other articles:
|
|
 |
|
  T. Kamala and N. K. Nanda Protective Response to Leishmania major in BALB/c Mice Requires Antigen Processing in the Absence of DM J. Immunol., April 15, 2009; 182(8): 4882 - 4890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson, R. Lira, S. Kamhawi, Y. Belkaid, T. A. Wynn, and D. Sacks IL-10 and TGF-{beta} Control the Establishment of Persistent and Transmissible Infections Produced by Leishmania tropica in C57BL/6 Mice J. Immunol., March 15, 2008; 180(6): 4090 - 4097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Elshafie, E. Ahlin, L. Mathsson, G. ElGhazali, and J. Ronnelid Circulating Immune Complexes (IC) and IC-Induced Levels of GM-CSF Are Increased in Sudanese Patients with Acute Visceral Leishmania donovani Infection Undergoing Sodium Stibogluconate Treatment: Implications for Disease Pathogenesis J. Immunol., April 15, 2007; 178(8): 5383 - 5389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis J. Exp. Med., February 19, 2007; 204(2): 285 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. M. Wanderley, M. E. C. Moreira, A. Benjamin, A. C. Bonomo, and M. A. Barcinski Mimicry of Apoptotic Cells by Exposing Phosphatidylserine Participates in the Establishment of Amastigotes of Leishmania (L) amazonensis in Mammalian Hosts J. Immunol., February 1, 2006; 176(3): 1834 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Woelbing, S. L. Kostka, K. Moelle, Y. Belkaid, C. Sunderkoetter, S. Verbeek, A. Waisman, A. P. Nigg, J. Knop, M. C. Udey, et al. Uptake of Leishmania major by dendritic cells is mediated by Fc{gamma} receptors and facilitates acquisition of protective immunity J. Exp. Med., January 23, 2006; 203(1): 177 - 188. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
