The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ibegbu, C. C.
Right arrow Articles by Kourtis, A. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ibegbu, C. C.
Right arrow Articles by Kourtis, A. P.
The Journal of Immunology, 2005, 174: 6088-6094.
Copyright © 2005 by The American Association of Immunologists

Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57

Chris C. Ibegbu*, Yong-Xian Xu*, Wayne Harris*, David Maggio*, Joseph D. Miller* and Athena P. Kourtis{dagger}

* Center for AIDS Research, Immunology Core Laboratory, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329; and {dagger} Eastern Virginia Medical School, Norfolk, VA 23501

Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like receptors expressed by NK cells and T lymphocytes, mainly CD8+ effector/memory cells that can secrete cytokines but have poor proliferative capacity. Using multiparameter flow cytometry, we studied KLRG1 expression on CD8+ T cells specific for epitopes of CMV, EBV, influenza, and HIV. Over 92% of CD8+ cells specific for CMV or EBV expressed KLRG1 during the latent stage of these chronic infections. CD8+ T cell cells specific for HIV epitopes were mostly (72–89%) KLRG1+, even though not quite at the level of predominance noted with CMV or EBV. Lower frequency of KLRG1 expression was observed among CD8+ cells specific for influenza (40–73%), a resolved infection without a latent stage. We further observed that CD8+ cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57–KLRG1+ cells was also identified. This population may represent a "memory" phenotype, because they also expressed CD27, CD28, CCR7, and CD127. In contrast, CD57+KLRG1+ cells did not express CD27, CD28, and CCR7, and expressed CD127 at a much lower frequency, indicating that they represent effector cells that are truly terminally differentiated. The combination of KLRG1 and CD57 expression might thus aid in refining functional characterization of CD8+ T cell subsets.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. C. Albareda, G. C. Olivera, S. A. Laucella, M. G. Alvarez, E. R. Fernandez, B. Lococo, R. Viotti, R. L. Tarleton, and M. Postan
Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence
J. Immunol., September 15, 2009; 183(6): 4103 - 4108.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Petrovas, B. Chaon, D. R. Ambrozak, D. A. Price, J. J. Melenhorst, B. J. Hill, C. Geldmacher, J. P. Casazza, P. K. Chattopadhyay, M. Roederer, et al.
Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection
J. Immunol., July 15, 2009; 183(2): 1120 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Touvrey, L. Derre, E. Devevre, P. Corthesy, P. Romero, N. Rufer, and D. E. Speiser
Dominant Human CD8 T Cell Clonotypes Persist Simultaneously as Memory and Effector Cells in Memory Phase
J. Immunol., June 1, 2009; 182(11): 6718 - 6726.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. C. Simons, S. E. VanCompernolle, R. M. Smith, J. Wei, L. Barnett, S. L. Lorey, D. Meyer-Olson, and S. A. Kalams
Despite Biased TRBV Gene Usage against a Dominant HLA B57-Restricted Epitope, TCR Diversity Can Provide Recognition of Circulating Epitope Variants
J. Immunol., October 1, 2008; 181(7): 5137 - 5146.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: I. NK cell receptor genes as determinants of HIV resistance and progression to AIDS
J. Leukoc. Biol., July 1, 2008; 84(1): 1 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Iannello, O. Debbeche, S. Samarani, and A. Ahmad
Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination
J. Leukoc. Biol., July 1, 2008; 84(1): 27 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. van Stijn, A. T. Rowshani, S. L. Yong, F. Baas, E. Roosnek, I. J. M. ten Berge, and R. A. W. van Lier
Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells
J. Immunol., April 1, 2008; 180(7): 4550 - 4560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Barcy, S. C. De Rosa, J. Vieira, K. Diem, M. Ikoma, C. Casper, and L. Corey
{gamma}{delta}+ T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection
J. Immunol., March 1, 2008; 180(5): 3417 - 3425.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. S. Joshi and S. M. Kaech
Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation
J. Immunol., February 1, 2008; 180(3): 1309 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Rezvani, A. S. M. Yong, B. N. Savani, S. Mielke, K. Keyvanfar, E. Gostick, D. A. Price, D. C. Douek, and A. J. Barrett
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
Blood, September 15, 2007; 110(6): 1924 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Derre, M. Bruyninx, P. Baumgaertner, E. Devevre, P. Corthesy, C. Touvrey, Y. D. Mahnke, H. Pircher, V. Voelter, P. Romero, et al.
In Vivo Persistence of Codominant Human CD8+ T Cell Clonotypes Is Not Limited by Replicative Senescence or Functional Alteration
J. Immunol., August 15, 2007; 179(4): 2368 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. S. Tessmer, C. Fugere, F. Stevenaert, O. V. Naidenko, H. J. Chong, G. Leclercq, and L. Brossay
KLRG1 binds cadherins and preferentially associates with SHIP-1
Int. Immunol., April 1, 2007; 19(4): 391 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. Bengsch, H. C. Spangenberg, N. Kersting, C. Neumann-Haefelin, E. Panther, F. von Weizsacker, H. E. Blum, H. Pircher, and R. Thimme
Analysis of CD127 and KLRG1 Expression on Hepatitis C Virus-Specific CD8+ T Cells Reveals the Existence of Different Memory T-Cell Subsets in the Peripheral Blood and Liver
J. Virol., January 15, 2007; 81(2): 945 - 953.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J. E. Leigh, K. M. McNulty, and P. L. Fidel Jr.
Characterization of the Immune Status of CD8+ T Cells in Oral Lesions of Human Immunodeficiency Virus-Infected Persons with Oropharyngeal Candidiasis
Clin. Vaccine Immunol., June 1, 2006; 13(6): 678 - 683.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Ito, T. Maruyama, N. Saito, S. Koganei, K. Yamamoto, and N. Matsumoto
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity
J. Exp. Med., February 21, 2006; 203(2): 289 - 295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2005 by The American Association of Immunologists, Inc. All rights reserved.