HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mo, R. Articles by Yung, R. L. Search for Related Content PubMed PubMed Citation Articles by Mo, R. Articles by Yung, R. L.

Estrogen Regulates CCR Gene Expression and Function in T Lymphocytes ¹

RuRan Mo^*, Jun Chen^*, Annabelle Grolleau-Julius^*, Hedwig S. Murphy, Bruce C. Richardson^* and Raymond L. Yung^2,*

Departments of^* Internal Medicine and Pathology, University of Michigan, Ann Arbor, MI 48109

Estrogen has been implicated in the observed female bias in autoimmune diseases. However, the mechanisms behind this gender dimorphism are poorly defined. We have previously reported that in vivo T cell trafficking is gender- and estrogen-dependent. Chemokine receptors are critical determinants of T cell homing and immune response. In this study, we show that the female gender is associated with increased CD4⁺ T cell CCR1-CCR5 gene and protein expression in mice. The increased CCR expression correlates with enhanced in vitro chemotaxis response to MIP-1 (CCL4). In vivo treatment of young oophorectomized and postmenopausal female mice with 17-estradiol also increased CD4⁺ T cell CCR expression. Finally, 17-estradiol enhances tyrosine phosphorylation in T cells stimulated with MIP-1 in a time-dependent manner. Our results indicate an important role of estrogen in determining T cell chemokine response that may help explain the increased susceptibility and severity of autoimmune diseases in females.

This article has been cited by other articles:

				S. H. Windahl, M. K. Lagerquist, N. Andersson, C. Jochems, A. Kallkopf, C. Hakansson, J. Inzunza, J.-A. Gustafsson, P. T. van der Saag, H. Carlsten, et al. Identification of Target Cells for the Genomic Effects of Estrogens in Bone Endocrinology, December 1, 2007; 148(12): 5688 - 5695. [Abstract] [Full Text] [PDF]

				F. J. Martinez, J. L. Curtis, F. Sciurba, J. Mumford, N. D. Giardino, G. Weinmann, E. Kazerooni, S. Murray, G. J. Criner, D. D. Sin, et al. Sex Differences in Severe Pulmonary Emphysema Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 243 - 252. [Abstract] [Full Text] [PDF]

				A. J. Lengi, R. A. Phillips, E. Karpuzoglu, and S. A. Ahmed Estrogen selectively regulates chemokines in murine splenocytes J. Leukoc. Biol., April 1, 2007; 81(4): 1065 - 1074. [Abstract] [Full Text] [PDF]

				A. Cernetich, L. S. Garver, A. E. Jedlicka, P. W. Klein, N. Kumar, A. L. Scott, and S. L. Klein Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect. Immun., June 1, 2006; 74(6): 3190 - 3203. [Abstract] [Full Text] [PDF]

				X. Jiang, B. A. Orr, D. M. Kranz, and D. J. Shapiro Estrogen Induction of the Granzyme B Inhibitor, Proteinase Inhibitor 9, Protects Cells against Apoptosis Mediated by Cytotoxic T Lymphocytes and Natural Killer Cells Endocrinology, March 1, 2006; 147(3): 1419 - 1426. [Abstract] [Full Text] [PDF]