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in Murine Schistosomiasis: Identification of Two Epistatic Genetic Intervals1
* Department of Pathology, Tufts University School of Medicine, Boston, MA 02111;
Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and
Institute of Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, MA 02111
The genetic basis of dissimilar immunopathology development among mouse strains infected with Schistosoma mansoni is not known. We performed a multipoint parametric linkage analysis on a cohort of F2 mice, offspring of brother-sister mating between (high pathology CBA x low pathology BL/6)F1 mice, to examine whether the observed differences in the type of immune response or the extent of hepatic immunopathology are linked to any particular genomic intervals. The F2 mice exhibited cytokine responses and immunopathologies that revealed a statistically significant correlation between prominent egg Ag-stimulated IFN-
production by mesenteric lymph node cells and hepatic egg granuloma size. Increased IFN- production showed suggestive linkage to a dominant CBA locus on chromosome 1 and a recessive CBA locus on chromosome 5; significantly, there was an epistatic interaction between the two IFN- loci. An additional locus with suggestive linkage to granuloma formation and a CBA-recessive mode of inheritance was mapped to centromeric chromosome 13. Our analysis identified the first three genetic regions that appear to influence the immunopathology in murine schistosomiasis; however, further congenic dissection studies will furnish a more precise understanding of the genetic control of this disease.
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