| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
B Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis1
* Institute of Neuroimmunology, Neuroscience Research Center, Charité, Berlin, Germany;
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands;
German Arthritis Research Center, Berlin, Germany;
Institute of Biochemistry, Charité, Berlin, Germany;
¶
Experimental Pathology, Department of Pathology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
Recent studies in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), point to the fact that even in the early phase of inflammation, neuronal pathology plays a pivotal role in the sustained disability of affected individuals. We show that the major green tea constituent, (–)-epigallocatechin-3-gallate (EGCG), dramatically suppresses EAE induced by proteolipid protein 139–151. EGCG reduced clinical severity when given at initiation or after the onset of EAE by both limiting brain inflammation and reducing neuronal damage. In orally treated mice, we found abrogated proliferation and TNF-
production of encephalitogenic T cells. In human myelin-specific CD4+ T cells, cell cycle arrest was induced, down-regulating the cyclin-dependent kinase 4. Interference with both T cell growth and effector function was mediated by blockade of the catalytic activities of the 20S/26S proteasome complex, resulting in intracellular accumulation of I
B- and subsequent inhibition of NF-B activation. Because its structure implicates additional antioxidative properties, EGCG was capable of protecting against neuronal injury in living brain tissue induced by N-methyl-D-aspartate or TRAIL and of directly blocking the formation of neurotoxic reactive oxygen species in neurons. Thus, a natural green tea constituent may open up a new therapeutic avenue for young disabled adults with inflammatory brain disease by combining, on one hand, anti-inflammatory and, on the other hand, neuroprotective capacities.
Related articles in The JI:
This article has been cited by other articles:
|
|
 |
|
  K.-C. Choi, M. G. Jung, Y.-H. Lee, J. C. Yoon, S. H. Kwon, H.-B. Kang, M.-J. Kim, J.-H. Cha, Y. J. Kim, W. J. Jun, et al. Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation Cancer Res., January 15, 2009; 69(2): 583 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Mandel, T. Amit, L. Kalfon, L. Reznichenko, and M. B. H. Youdim Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins J. Nutr., August 1, 2008; 138(8): 1578S - 1583S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cabrelle, I. Dell'Aica, L. Melchiori, S. Carraro, E. Brunetta, R. Niero, E. Scquizzato, G. D'Intino, L. Calza, S. Garbisa, et al. Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease J. Leukoc. Biol., January 1, 2008; 83(1): 212 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Wang, J. Qiu, T. B. Guo, A. Liu, Y. Wang, Y. Li, and J. Z. Zhang Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis J. Immunol., November 1, 2007; 179(9): 5958 - 5965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Haddad, G. A. Azar, S. Groom, and M. Boivin Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases Evid. Based Complement. Altern. Med., December 1, 2005; 2(4): 513 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hsu, D. P. Dickinson, H. Qin, C. Lapp, D. Lapp, J. Borke, D. S. Walsh, W. B. Bollag, H. Stoppler, T. Yamamoto, et al. Inhibition of Autoantigen Expression by (-)-Epigallocatechin-3-gallate (the Major Constituent of Green Tea) in Normal Human Cells J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 805 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Rezai-Zadeh, D. Shytle, N. Sun, T. Mori, H. Hou, D. Jeanniton, J. Ehrhart, K. Townsend, J. Zeng, D. Morgan, et al. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice J. Neurosci., September 21, 2005; 25(38): 8807 - 8814. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D'Intino, M. Paradisi, M. Fernandez, A. Giuliani, L. Aloe, L. Giardino, and L. Calza Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats PNAS, February 22, 2005; 102(8): 3070 - 3075. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
