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Departments of
*
Pathology and Laboratory Medicine and
Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
Listeriosis is an infectious disease caused by the bacterium Listeria monocytogenes. Although it is well recognized that apoptosis plays a critical role in the pathogenesis of the disease, the molecular mechanisms of cell death in listeriosis remain to be established. We report in this study that mice deficient in TRAIL were partially resistant to primary listeriosis, and blocking TRAIL with a soluble death receptor 5 markedly ameliorated the disease. The numbers of Listeria in the liver and spleen of TRAIL+/+ mice were 10–100 times greater than those in TRAIL–/– mice following primary Listeria infection. This was accompanied by a significant increase in the survival rate of TRAIL–/– mice. Lymphoid and myeloid cell death was significantly inhibited in TRAIL–/– mice, which led to marked enlargement of the spleen. These results establish a critical role for TRAIL in apoptosis during listeriosis.
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