| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology, Mayo Clinic, Rochester, MN 55905; and
Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210
B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8+ CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8+ CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.
This article has been cited by other articles:
|
|
 |
|
  O. Nagashima, N. Harada, Y. Usui, T. Yamazaki, H. Yagita, K. Okumura, K. Takahashi, and H. Akiba B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma J. Immunol., September 15, 2008; 181(6): 4062 - 4071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hashiguchi, H. Kobori, P. Ritprajak, Y. Kamimura, H. Kozono, and M. Azuma From the Cover: Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses PNAS, July 29, 2008; 105(30): 10495 - 10500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Hofmeyer, A. Ray, and X. Zang The contrasting role of B7-H3 PNAS, July 29, 2008; 105(30): 10277 - 10278. [Full Text] [PDF]
|
|
|
|
|
|
C. N. Tran, S. G. Thacker, D. M. Louie, J. Oliver, P. T. White, J. L. Endres, A. G. Urquhart, K. C. Chung, and D. A. Fox Interactions of T Cells with Fibroblast-Like Synoviocytes: Role of the B7 Family Costimulatory Ligand B7-H3 J. Immunol., March 1, 2008; 180(5): 2989 - 2998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zang, R. H. Thompson, H. A. Al-Ahmadie, A. M. Serio, V. E. Reuter, J. A. Eastham, P. T. Scardino, P. Sharma, and J. P. Allison B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome PNAS, December 4, 2007; 104(49): 19458 - 19463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Roth, Y. Sheinin, C. M. Lohse, S. M. Kuntz, X. Frigola, B. A. Inman, A. E. Krambeck, M. E. Mckenney, R. J. Karnes, M. L. Blute, et al. B7-H3 Ligand Expression by Prostate Cancer: A Novel Marker of Prognosis and Potential Target for Therapy Cancer Res., August 15, 2007; 67(16): 7893 - 7900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhu, G. Zhu, L. Luo, A. S. Flies, and L. Chen CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype Blood, June 1, 2007; 109(11): 4882 - 4889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-K. Suh, S. Wang, G. S. Duncan, Y. Miyazaki, E. Cates, T. Walker, B. U. Gajewska, E. Deenick, W. Dawicki, H. Okada, et al. Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice. Mol. Cell. Biol., September 1, 2006; 26(17): 6403 - 6411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Petroff, E. Kharatyan, D. S. Torry, and L. Holets The Immunomodulatory Proteins B7-DC, B7-H2, and B7-H3 Are Differentially Expressed across Gestation in the Human Placenta Am. J. Pathol., August 1, 2005; 167(2): 465 - 473. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
