| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Program in Immunology and Virology, Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655
Virus-specific CD8 T cells after clearance of infection reduce their number in lymphoid organs by apoptotic death and by migration into peripheral tissues. During and after infection, many lymphocytic choriomeningitis virus (LCMV)-specific CD8 T cells in lymphoid but not peripheral tissues are in a preapoptotic state, as detected by the early apoptosis marker annexin V. In this report, we investigated the significance of this preapoptotic state and how it may be influenced by viral epitope specificity. Stimulation with anti-CD3 or IL-2 in vitro postponed DNA fragmentation in annexin V+ cells, but adoptive transfer studies in vivo showed that this preapoptotic phenotype precluded the development of functional memory. CD8 T cells specific to LCMV epitopes NP396 and gp33 differed in their preapoptotic state, with NP396-specific T cells binding more annexin V than gp33-specific T cells. These epitope- and tissue-dependent differences were seen in primary, memory, and secondary responses and in mice receiving different displays of Ag by infection with LCMV strains of different tropisms or by infection with vaccinia virus recombinants expressing LCMV proteins. Thus, the epitope-dependent differences in apoptosis were independent of virus tropisms, duration of Ag exposure, and competition within APCs, and were an intrinsic property of the epitope. The tissue-dependent and epitope-dependent preapoptotic state correlated with reduced expression of IL-7R
.
This article has been cited by other articles:
|
|
 |
|
  M. G. H. Hernandez, L. Shen, and K. L. Rock CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help J. Immunol., April 1, 2008; 180(7): 4382 - 4390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-J. Lin, C. D. Peacock, K. Bahl, and R. M. Welsh Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation J. Exp. Med., October 1, 2007; 204(10): 2321 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Genesca, T. Rourke, J. Li, K. Bost, B. Chohan, M. B. McChesney, and C. J. Miller Live Attenuated Lentivirus Infection Elicits Polyfunctional Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells with Reduced Apoptotic Susceptibility in Rhesus Macaques that Control Virus Replication after Challenge with Pathogenic SIVmac239 J. Immunol., October 1, 2007; 179(7): 4732 - 4740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Kersh Impaired Memory CD8 T Cell Development in the Absence of Methyl-CpG-Binding Domain Protein 2 J. Immunol., September 15, 2006; 177(6): 3821 - 3826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jabbari, K. L. Legge, and J. T. Harty T cell conditioning explains early disappearance of the memory CD8 T cell response to infection. J. Immunol., September 1, 2006; 177(5): 3012 - 3018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yajima, K. Yoshihara, K. Nakazato, S. Kumabe, S. Koyasu, S. Sad, H. Shen, H. Kuwano, and Y. Yoshikai IL-15 Regulates CD8+ T Cell Contraction during Primary Infection J. Immunol., January 1, 2006; 176(1): 507 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Su, R. E. Berg, S. Murray, and J. Forman Thymus-Dependent Memory Phenotype CD8 T Cells in Naive B6.H-2Kb-/-Db-/- Animals Mediate an Antigen-Specific Response against Listeria monocytogenes J. Immunol., November 15, 2005; 175(10): 6450 - 6457. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
