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,
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Departments of
*
Molecular Microbiology and Immunology and
Cardiology, Oregon Health and Science University, Portland, OR 97239;
Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213; and
Immunology Research, Veterans Affairs Medical Center, Portland, OR 97239
The immunologic requirements for generating long-lived protective CD8 T cell memory remain unclear. Memory CD8 populations generated in the absence of CD4 Th cells reportedly have functional defects, and at least a subset of CD8 T cells transiently express CD40 after activation, suggesting that direct CD4-CD8 T cell interactions through CD40 may influence the magnitude and functional quality of memory CD8 populations. To ascertain the role of CD40 in such direct T cell interactions, we investigated CD8 T cell responses in CD40–/– mice after infection with Listeria monocytogenes, an intracellular bacterium that induces APC activation and thus priming of CD8 T cells independently of CD4 Th cell help through CD40. In this study we show that memory CD8 T cells generated in CD40-deficient mice show in vivo cytotoxicity and cytokine production equivalent to CD8 memory T cells from wild-type mice. Upon secondary Listeria infection, CD40–/– memory CD8 T cells expand to greater numbers than seen in wild-type mice. These results indicate that CD40 ligation on CD8 T cells, although reportedly a part of CD8 T cell memory development in an H-Y-directed response, is not needed for the development of functional memory CD8 T cell populations after Listeria infection.
This article has been cited by other articles:
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  L. Rapetti, S. Meunier, C. Pontoux, and C. Tanchot CD4 Help Regulates Expression of Crucial Genes Involved in CD8 T Cell Memory and Sensitivity to Regulatory Elements J. Immunol., July 1, 2008; 181(1): 299 - 308. [Abstract] [Full Text] [PDF]
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M. G. H. Hernandez, L. Shen, and K. L. Rock CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8+ T Cell Memory Even in the Absence of CD4+ T Cell Help J. Immunol., April 1, 2008; 180(7): 4382 - 4390. [Abstract] [Full Text] [PDF]
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P. Agnellini, M. Wiesel, K. Schwarz, P. Wolint, M. F. Bachmann, and A. Oxenius Kinetic and Mechanistic Requirements for Helping CD8 T Cells J. Immunol., February 1, 2008; 180(3): 1517 - 1525. [Abstract] [Full Text] [PDF]
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P. Otahal, B. B. Knowles, S. S. Tevethia, and T. D. Schell Anti-CD40 Conditioning Enhances the TCD8 Response to a Highly Tolerogenic Epitope and Subsequent Immunotherapy of Simian Virus 40 T Antigen-Induced Pancreatic Tumors J. Immunol., November 15, 2007; 179(10): 6686 - 6695. [Abstract] [Full Text] [PDF]
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 M. Shi, S. Hao, T. Chan, and J. Xiang CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion J. Leukoc. Biol., December 1, 2006; 80(6): 1354 - 1363. [Abstract] [Full Text] [PDF]
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