HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Van Themsche, C. Articles by St-Pierre, Y. Search for Related Content PubMed PubMed Citation Articles by Van Themsche, C. Articles by St-Pierre, Y.

Stromelysin-2 (Matrix Metalloproteinase 10) Is Inducible in Lymphoma Cells and Accelerates the Growth of Lymphoid Tumors In Vivo¹

Céline Van Themsche^*, Tommy Alain, Anna E. Kossakowska, Stefan Urbanski, Édouard F. Potworowski^* and Yves St-Pierre^2,*

^* Institut National de la Recherche Scientifique-Institut Armand-Frappier, University of Québec, Laval, Canada; and Department of Pathology, University of Calgary and Calgary Laboratory Services, Calgary, Canada

Matrix metalloproteinase (MMP) 10 (stromelysin-2) is known to degrade various components of the extracellular matrix; however, the signals that regulate its expression and its role in lymphoma growth remain unknown. In the present work, we report the up-regulated expression of MMP10 in T lymphoma cells following contact with endothelial cells. The induction of MMP10 was found to be dependent on the specific interaction between LFA-1 and ICAM-1, which play a central role in regulating the expression of genes involved in the rate-limiting steps of lymphoma development. MMP10, but not MMP3 (stromelysin-1), was also up-regulated in human B lymphoma cells following exposure to IL-4, IL-6, and IL-13, but not to IL-1. To gain further insight into the role of MMP10 in lymphoma development, we generated lymphoma cell lines constitutively expressing high levels of MMP10 and studied these cells for their ability to form thymic lymphoma in vivo. Mice injected with lymphoma cells constitutively expressing MMP10 developed thymic lymphoma more rapidly than those injected with control lymphoma cells. These results provide the first in vivo evidence that overexpression of MMP10 promotes tumor development, and indicate that MMP10 induction is an important pathway activated not only upon ICAM-1/LFA-1-mediated intercellular contact, but also following activation of tumor cells with inflammatory cytokines.

This article has been cited by other articles:

				S. J. Blossom and K. M. Gilbert Exposure to a Metabolite of the Environmental Toxicant, Trichloroethylene, Attenuates CD4+ T Cell Activation-Induced Cell Death by Metalloproteinase-Dependent FasL Shedding Toxicol. Sci., July 1, 2006; 92(1): 103 - 114. [Abstract] [Full Text] [PDF]

				A. Coxon, E. Rozenblum, Y.-S. Park, N. Joshi, J. Tsurutani, P. A. Dennis, I. R. Kirsch, and F. J. Kaye Mect1-Maml2 Fusion Oncogene Linked to the Aberrant Activation of Cyclic AMP/CREB Regulated Genes Cancer Res., August 15, 2005; 65(16): 7137 - 7144. [Abstract] [Full Text] [PDF]

				L. Belkacemi, G. E. Lash, S. K. Macdonald-Goodfellow, J. D. Caldwell, and C. H. Graham Inhibition of Human Trophoblast Invasiveness by High Glucose Concentrations J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4846 - 4851. [Abstract] [Full Text] [PDF]

				G. E. Lash, H. A. Otun, B. A. Innes, J. N. Bulmer, R. F. Searle, and S. C. Robson Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases Biol Reprod, August 1, 2005; 73(2): 374 - 381. [Abstract] [Full Text] [PDF]