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The Journal of Immunology, 2004, 173: 3594-3598.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Murine Dendritic Cells Require IL-15R{alpha} to Prime NK Cells1

Rima Koka, Patrick Burkett, Marcia Chien, Sophia Chai, David L. Boone and Averil Ma2

Department of Medicine, University of California, San Francisco, CA 94143

NK cells protect hosts against viral pathogens and transformed cells, and dendritic cells (DCs) play important roles in activating NK cells. We now find that murine IL-15R{alpha}-deficient DCs fail to support NK cell cytolytic activity and elaboration of IFN-{gamma}, despite the fact that these DCs express normal levels of costimulatory molecules and IL-12. By contrast, IL-15R{alpha} expression on NK cells is entirely dispensable for their activation by DCs. In addition, blockade with anti-IL-15R{alpha} and anti-IL-2R{beta} but not anti-IL-2R{alpha}-specific Abs prevents NK cell activation by wild-type DCs. Finally, presentation of IL-15 by purified IL-15R{alpha}/Fc in trans synergizes with IL-12 to support NK cell priming. These findings suggest that murine DCs require IL-15R{alpha} to present IL-15 in trans to NK cells during NK cell priming.


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