The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by La Cava, A.
Right arrow Articles by Hahn, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by La Cava, A.
Right arrow Articles by Hahn, B. H.
The Journal of Immunology, 2004, 173: 3542-3548.
Copyright © 2004 by The American Association of Immunologists

Ig-Reactive CD4+CD25+ T Cells from Tolerized (New Zealand Black x New Zealand White)F1 Mice Suppress In Vitro Production of Antibodies to DNA1

Antonio La Cava2, Fanny M. Ebling and Bevra H. Hahn

Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

We have recently shown that tolerogenic administration of an artificial peptide (pConsensus) that is based on sequences within the VH regions of several murine anti-dsDNA Ig delays appearance of autoantibodies in female (New Zealand Black (NZB) x New Zealand White (NZW))F1 (NZB/W F1) mice and significantly prolongs their survival. The aim of this study was to characterize the T cell population(s) involved in pConsensus-induced down-regulation of autoimmune responses in tolerized NZB/W F1 mice. Using MHC class II dimers loaded with tolerogenic peptide, we found that pCons favored expansion of peptide-reactive CD4+CD25+ regulatory T cells (TR) that inhibited in vitro production of anti-dsDNA Ab-forming cells. Suppression by TR was abrogated by the presence in culture of Ab to glucocorticoid-induced TNFR family member 18 or to TGF{beta} latency-associated protein. These findings suggest possible relevance of Ag specificity in the mechanism of TR-mediated immune tolerance to Ig-derived peptides in NZB/W F1 mice.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. Zhang, A. M. Bertucci, R. Ramsey-Goldman, R. K. Burt, and S. K. Datta
Regulatory T Cell (Treg) Subsets Return in Patients with Refractory Lupus following Stem Cell Transplantation, and TGF-{beta}-Producing CD8+ Treg Cells Are Associated with Immunological Remission of Lupus
J. Immunol., November 15, 2009; 183(10): 6346 - 6358.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Iikuni, E. V. Lourenco, B. H. Hahn, and A. La Cava
Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus
J. Immunol., August 1, 2009; 183(3): 1518 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. V. Lourenco, C. Procaccini, F. Ferrera, N. Iikuni, R. P. Singh, G. Filaci, G. Matarese, F.-D. Shi, E. Brahn, B. H. Hahn, et al.
Modulation of p38 MAPK Activity in Regulatory T Cells after Tolerance with Anti-DNA Ig Peptide in (NZB x NZW)F1 Lupus Mice
J. Immunol., June 15, 2009; 182(12): 7415 - 7421.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
H. Wu, E. Center, G. Tsokos, and H. Weiner
Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
Lupus, June 1, 2009; 18(7): 586 - 596.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
J. Abe, S. Ueha, J. Suzuki, Y. Tokano, K. Matsushima, and S. Ishikawa
Increased Foxp3+ CD4+ Regulatory T Cells with Intact Suppressive Activity but Altered Cellular Localization in Murine Lupus
Am. J. Pathol., December 1, 2008; 173(6): 1682 - 1692.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Y. Wu, F. J. Quintana, and H. L. Weiner
Nasal Anti-CD3 Antibody Ameliorates Lupus by Inducing an IL-10-Secreting CD4+CD25-LAP+ Regulatory T Cell and Is Associated with Down-Regulation of IL-17+CD4+ICOS+CXCR5+ Follicular Helper T Cells
J. Immunol., November 1, 2008; 181(9): 6038 - 6050.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Sharabi and E. Mozes
The Suppression of Murine Lupus by a Tolerogenic Peptide Involves Foxp3-Expressing CD8 Cells That Are Required for the Optimal Induction and Function of Foxp3-Expressing CD4 Cells
J. Immunol., September 1, 2008; 181(5): 3243 - 3251.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A La Cava
T-regulatory cells in systemic lupus erythematosus
Lupus, May 1, 2008; 17(5): 421 - 425.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
R. P. Singh, A. La Cava, and B. H. Hahn
pConsensus Peptide Induces Tolerogenic CD8+ T Cells in Lupus-Prone (NZB x NZW)F1 Mice by Differentially Regulating Foxp3 and PD1 Molecules
J. Immunol., February 15, 2008; 180(4): 2069 - 2080.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. M. Cuda, S. Wan, E. S. Sobel, B. P. Croker, and L. Morel
Murine Lupus Susceptibility Locus Sle1a Controls Regulatory T Cell Number and Function through Multiple Mechanisms
J. Immunol., December 1, 2007; 179(11): 7439 - 7447.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. P. Singh, A. La Cava, M. Wong, F. Ebling, and B. H. Hahn
CD8+ T Cell-Mediated Suppression of Autoimmunity in a Murine Lupus Model of Peptide-Induced Immune Tolerance Depends on Foxp3 Expression
J. Immunol., June 15, 2007; 178(12): 7649 - 7657.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. R. Kim, E. Y. Kim, J. Cerny, and K. D. Moudgil
Antibody Responses to Mycobacterial and Self Heat Shock Protein 65 in Autoimmune Arthritis: Epitope Specificity and Implication in Pathogenesis
J. Immunol., November 15, 2006; 177(10): 6634 - 6641.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. J. Scalapino, Q. Tang, J. A. Bluestone, M. L. Bonyhadi, and D. I. Daikh
Suppression of Disease in New Zealand Black/New Zealand White Lupus-Prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells
J. Immunol., August 1, 2006; 177(3): 1451 - 1459.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Sharabi, H. Zinger, M. Zborowsky, Z. M. Sthoeger, and E. Mozes
A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta
PNAS, June 6, 2006; 103(23): 8810 - 8815.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Zhang, I. Todorov, Z. Zhang, Y. Liu, F. Kandeel, S. Forman, S. Strober, and D. Zeng
Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations
Blood, April 1, 2006; 107(7): 2993 - 3001.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. H. Hahn, R. P. Singh, A. La Cava, and F. M. Ebling
Tolerogenic Treatment of Lupus Mice with Consensus Peptide Induces Foxp3-Expressing, Apoptosis-Resistant, TGF{beta}-Secreting CD8+ T Cell Suppressors
J. Immunol., December 1, 2005; 175(11): 7728 - 7737.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. E. Wither, C. Loh, G. Lajoie, S. Heinrichs, Y.-C. Cai, G. Bonventi, and R. MacLeod
Colocalization of Expansion of the Splenic Marginal Zone Population with Abnormal B Cell Activation and Autoantibody Production in B6 Mice with an Introgressed New Zealand Black Chromosome 13 Interval
J. Immunol., October 1, 2005; 175(7): 4309 - 4319.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Bagavant and K. S. K. Tung
Failure of CD25+ T Cells from Lupus-Prone Mice to Suppress Lupus Glomerulonephritis and Sialoadenitis
J. Immunol., July 15, 2005; 175(2): 944 - 950.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.