The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jang, S.
Right arrow Articles by Salgame, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jang, S.
Right arrow Articles by Salgame, P.
The Journal of Immunology, 2004, 173: 3392-3397.
Copyright © 2004 by The American Association of Immunologists

IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition1

Sihyug Jang2,*, Satoshi Uematsu{dagger}, Shizuo Akira{dagger} and Padmini Salgame3,*

* Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia PA 19140; and {dagger} Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

The initial TLR-mediated interaction between Mycobacterium tuberculosis and dendritic cells is critical, since the cytokine production that ensues can greatly influence the class of adaptive immunity that is generated to the pathogen. In this study, we therefore determined the dependency on TLR2 and TLR4 for M. tuberculosis-induced cytokine production by murine dendritic cells. A key new finding of this study is that production of IL-6 and IL-10 from dendritic cells in response to M. tuberculosis is principally dependent on TLR2. The study also indicates that M. tuberculosis can induce IL-12 production in the absence of either TLR2 or TLR4, suggesting redundancy or possibly involvement of other receptors in IL-12 production. In addition, the data also reveal that lack of TLR2 or TLR4 does not impact on dendritic cell maturation or on their ability to influence the polarity of differentiating naive T cells. Collectively, data presented here provide a mechanistic insight for the contribution of TLR2 and TLR4 to tuberculosis disease progression and offer strategies for regulating IL-6 and IL-10 production in dendritic cell-based vaccine strategies.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. S. Almeida, P. M. Lago, N. Boechat, R. C. Huard, L. C. O. Lazzarini, A. R. Santos, M. Nociari, H. Zhu, B. M. Perez-Sweeney, H. Bang, et al.
Tuberculosis Is Associated with a Down-Modulatory Lung Immune Response That Impairs Th1-Type Immunity
J. Immunol., July 1, 2009; 183(1): 718 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Gonzalez-Juarrero, L. C. Kingry, D. J. Ordway, M. Henao-Tamayo, M. Harton, R. J. Basaraba, W. H. Hanneman, I. M. Orme, and R. A. Slayden
Immune Response to Mycobacterium tuberculosis and Identification of Molecular Markers of Disease
Am. J. Respir. Cell Mol. Biol., April 1, 2009; 40(4): 398 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Bhatt, A. Uzelac, S. Mathur, A. McBride, J. Potian, and P. Salgame
B7 Costimulation Is Critical for Host Control of Chronic Mycobacterium tuberculosis Infection
J. Immunol., March 15, 2009; 182(6): 3793 - 3800.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
F. Gerosa, B. Baldani-Guerra, L. A. Lyakh, G. Batoni, S. Esin, R. T. Winkler-Pickett, M. R. Consolaro, M. De Marchi, D. Giachino, A. Robbiano, et al.
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells
J. Exp. Med., June 9, 2008; 205(6): 1447 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. N. Couper, D. G. Blount, and E. M. Riley
IL-10: The Master Regulator of Immunity to Infection
J. Immunol., May 1, 2008; 180(9): 5771 - 5777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Q. Wu, R. J. Martin, S. LaFasto, B. J. Efaw, J. G. Rino, R. J. Harbeck, and H. W. Chu
Toll-like Receptor 2 Down-regulation in Established Mouse Allergic Lungs Contributes to Decreased Mycoplasma Clearance
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 720 - 729.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Gandotra, S. Jang, P. J. Murray, P. Salgame, and S. Ehrt
Nucleotide-Binding Oligomerization Domain Protein 2-Deficient Mice Control Infection with Mycobacterium tuberculosis
Infect. Immun., November 1, 2007; 75(11): 5127 - 5134.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. G. Rothfuchs, A. Bafica, C. G. Feng, J. G. Egen, D. L. Williams, G. D. Brown, and A. Sher
Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells
J. Immunol., September 15, 2007; 179(6): 3463 - 3471.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Pompei, S. Jang, B. Zamlynny, S. Ravikumar, A. McBride, S. P. Hickman, and P. Salgame
Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs
J. Immunol., April 15, 2007; 178(8): 5192 - 5199.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. J. Skerrett, C. B. Wilson, H. D. Liggitt, and A. M. Hajjar
Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L312 - L322.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Kurtz, K. P. McKinnon, M. S. Runge, J. P.-Y. Ting, and M. Braunstein
The SecA2 Secretion Factor of Mycobacterium tuberculosis Promotes Growth in Macrophages and Inhibits the Host Immune Response
Infect. Immun., December 1, 2006; 74(12): 6855 - 6864.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Touil, D. Fitzgerald, G.-X. Zhang, A. Rostami, and B. Gran
Cutting Edge: TLR3 Stimulation Suppresses Experimental Autoimmune Encephalomyelitis by Inducing Endogenous IFN-beta
J. Immunol., December 1, 2006; 177(11): 7505 - 7509.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Giacomini, A. Sotolongo, E. Iona, M. Severa, M. E. Remoli, V. Gafa, R. Lande, L. Fattorini, I. Smith, R. Manganelli, et al.
Infection of Human Dendritic Cells with a Mycobacterium tuberculosis sigE Mutant Stimulates Production of High Levels of Interleukin-10 but Low Levels of CXCL10: Impact on the T-Cell Response.
Infect. Immun., June 1, 2006; 74(6): 3296 - 3304.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Bafica, C. A. Scanga, C. G. Feng, C. Leifer, A. Cheever, and A. Sher
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
J. Exp. Med., December 19, 2005; 202(12): 1715 - 1724.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Shi, A. Blumenthal, C. M. Hickey, S. Gandotra, D. Levy, and S. Ehrt
Expression of Many Immunologically Important Genes in Mycobacterium tuberculosis-Infected Macrophages Is Independent of Both TLR2 and TLR4 but Dependent on IFN-{alpha}{beta} Receptor and STAT1
J. Immunol., September 1, 2005; 175(5): 3318 - 3328.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.