HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pereira, P. Articles by Boucontet, L. Search for Related Content PubMed PubMed Citation Articles by Pereira, P. Articles by Boucontet, L.

Rates of Recombination and Chain Pair Biases Greatly Influence the Primary TCR Repertoire in the Thymus of Adult Mice¹

Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, Paris, France

Analyses of the rearrangement status of the TCR and TCR chain loci in progenies of individual thymocytes showed a hierarchy of the different V and V gene segments to participate in a recombination reaction. Moreover, individual TCR chains only pair efficiently with a variable number of TCR chains. Interestingly, these two parameters are inversely correlated such that the TCR and TCR chains that rearrange more often show a higher level of restriction in their pairing capabilities. Our data suggest that these mechanisms, together with a natural variation affecting the expected frequencies at which rearrangement of different V gene segments give raise to functional TCR chains, have coevolved to maximize the diversity of the TCR repertoire minimizing the risk that a T cell will express more than one TCR specificity at the cell surface, despite the fact that multiple TCR rearrangements take place in the same progenitor cell.

This article has been cited by other articles:

				I. Ueda-Hayakawa, J. Mahlios, and Y. Zhuang Id3 Restricts the Developmental Potential of {gamma}{delta} Lineage during Thymopoiesis J. Immunol., May 1, 2009; 182(9): 5306 - 5316. [Abstract] [Full Text] [PDF]

				M. L. Joachims, J. L. Chain, S. W. Hooker, C. J. Knott-Craig, and L. F. Thompson Human {alpha}beta and {gamma}{delta} Thymocyte Development: TCR Gene Rearrangements, Intracellular TCRbeta Expression, and {gamma}{delta} Developmental Potential--Differences between Men and Mice J. Immunol., February 1, 2006; 176(3): 1543 - 1552. [Abstract] [Full Text] [PDF]

				S. Shin, R. El-Diwany, S. Schaffert, E. J. Adams, K. C. Garcia, P. Pereira, and Y.-h. Chien Antigen Recognition Determinants of {gamma}{delta} T Cell Receptors Science, April 8, 2005; 308(5719): 252 - 255. [Abstract] [Full Text] [PDF]

				L. Boucontet, N. Sepulveda, J. Carneiro, and P. Pereira Mechanisms Controlling Termination of V-J Recombination at the TCR{gamma} Locus: Implications for Allelic and Isotypic Exclusion of TCR{gamma} Chains J. Immunol., April 1, 2005; 174(7): 3912 - 3919. [Abstract] [Full Text] [PDF]