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*Substance via MeSH
Medline Plus Health Information
*Diabetes
The Journal of Immunology, 2004, 173: 3112-3118.
Copyright © 2004 by The American Association of Immunologists

Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells1

Nadia Duarte2,*,{dagger}, Martin Stenström2,{ddagger}, Susana Campino*,{dagger}, Marie-Louise Bergman*,{dagger}, Marie Lundholm*, Dan Holmberg*,{dagger},§ and Susanna L. Cardell3,{ddagger}

* Department of Medical Biosciences, Medical and Clinical Genetics, Umeå University, Umeå, Sweden; {dagger} The Gulbenkian Institute for Science, Oeiras, Portugal; {ddagger} Section for Immunology, Lund University, Lund, Sweden; and § Department of Clinical Genetics, Norrland University Hospital, Umeå, Sweden

A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type 1 diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the V{alpha}14-J{alpha}18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR V{alpha}3.2+V{beta}9+ NKT cells producing high levels of IFN-{gamma} but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes.




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