| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
* Department of Medical Biosciences, Medical and Clinical Genetics, Umeå University, Umeå, Sweden;
The Gulbenkian Institute for Science, Oeiras, Portugal;
Section for Immunology, Lund University, Lund, Sweden; and
Department of Clinical Genetics, Norrland University Hospital, Umeå, Sweden
A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type 1 diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the V
14-J18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR V3.2+V
9+ NKT cells producing high levels of IFN-
but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes.
This article has been cited by other articles:
|
|
 |
|
  M. I. Zimmer, H. P. Nguyen, B. Wang, H. Xu, A. Colmone, K. Felio, H.-J. Choi, P. Zhou, M.-L. Alegre, and C.-R. Wang Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells PNAS, February 10, 2009; 106(6): 1909 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. I. Koh, H. Y. Kim, E. H. Meyer, M. Pichavant, O. Akbari, T. Yasumi, P. B. Savage, R. H. DeKruyff, and D. T. Umetsu Activation of Nonclassical CD1d-Restricted NK T Cells Induces Airway Hyperreactivity in {beta}2-Microglobulin-Deficient Mice J. Immunol., October 1, 2008; 181(7): 4560 - 4569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Berzofsky and M. Terabe NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis J. Immunol., March 15, 2008; 180(6): 3627 - 3635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Kim, E. Y. Choi, and D. H. Chung Donor Bone Marrow Type II (Non-V{alpha}14J{alpha}18 CD1d-Restricted) NKT Cells Suppress Graft-Versus-Host Disease by Producing IFN-{gamma} and IL-4 J. Immunol., November 15, 2007; 179(10): 6579 - 6587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ambrosino, M. Terabe, R. C. Halder, J. Peng, S. Takaku, S. Miyake, T. Yamamura, V. Kumar, and J. A. Berzofsky Cross-Regulation between Type I and Type II NKT Cells in Regulating Tumor Immunity: A New Immunoregulatory Axis J. Immunol., October 15, 2007; 179(8): 5126 - 5136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakuishi, S. Oki, M. Araki, S. A. Porcelli, S. Miyake, and T. Yamamura Invariant NKT Cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation J. Immunol., September 15, 2007; 179(6): 3452 - 3462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lin, M. Nieda, J. F. Hutton, V. Rozenkov, and A. J. Nicol Comparative gene expression analysis of NKT cell subpopulations J. Leukoc. Biol., July 1, 2006; 80(1): 164 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Cain, J. A. Smith, J. K. Ondr, B. Wang, and J. D. Katz NKT Cells and IFN-{gamma} Establish the Regulatory Environment for the Control of Diabetogenic T Cells in the Nonobese Diabetic Mouse J. Immunol., February 1, 2006; 176(3): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Kent, Y. Chen, S. M. Clemmings, V. Viglietta, N. S. Kenyon, C. Ricordi, B. Hering, and D. A. Hafler Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells J. Immunol., October 1, 2005; 175(7): 4458 - 4464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Skold, X. Xiong, P. A. Illarionov, G. S. Besra, and S. M. Behar Interplay of Cytokines and Microbial Signals in Regulation of CD1d Expression and NKT Cell Activation J. Immunol., September 15, 2005; 175(6): 3584 - 3593. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
