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Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202
The uveitogenic T cells that mediate experimental autoimmune uveitis are commonly assumed to be exclusively CD4+. In the present study, we showed that, although a panel of long-term cultured rat uveitogenic T cell lines specific for the interphotoreceptor retinal-binding protein peptide, R16, all expressed CD4, 
40% of the R16-specific uveitogenic T cells freshly prepared from Ag-immunized rats were CD8+
TCR+, as demonstrated by CFSE staining. We showed that the expansion of these CD8+TCR+ T cells was Ag-specific and that highly purified CD8+ R16-specific T cells were able to induce uveitis on transfusion into naive rats. Moreover, CD8+ uveitogenic T cells more readily switched phenotype from, and to, TCR–CD8–CD4– during in vivo or in vitro activation compared with their CD4+ counterparts. In a previous study, we showed that highly purified CD8+ myelin oligodendrocyte glycoprotein-specific T cells induced more severe autoimmune encephalomyelitis than the corresponding CD4+ T cells. In this study, we show that an interphotoreceptor retinal-binding protein peptide consistently activated a high proportion of CD8+TCR+ T cells, which were uveitogenic in Lewis rats.
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