The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rosen, D. B.
Right arrow Articles by Lanier, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rosen, D. B.
Right arrow Articles by Lanier, L. L.
The Journal of Immunology, 2004, 173: 2470-2478.
Copyright © 2004 by The American Association of Immunologists

A Structural Basis for the Association of DAP12 with Mouse, but Not Human, NKG2D1

David B. Rosen*, Manabu Araki2,{dagger}, Jessica A. Hamerman*, Taian Chen*, Takashi Yamamura{dagger} and Lewis L. Lanier3,*

* Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143; and {dagger} Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo

Prior studies have revealed that alternative mRNA splicing of the mouse NKG2D gene generates receptors that associate with either the DAP10 or DAP12 transmembrane adapter signaling proteins. We report that NKG2D function is normal in human patients lacking functional DAP12, indicating that DAP10 is sufficient for human NKG2D signal transduction. Further, we show that human NKG2D is incapable of associating with DAP12 and provide evidence that structural differences in the transmembrane of mouse and human NKG2D account for the species-specific difference for this immune receptor.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. I. Whang, N. Guerra, and D. H. Raulet
Costimulation of Dendritic Epidermal {gamma}{delta} T Cells by a New NKG2D Ligand Expressed Specifically in the Skin
J. Immunol., April 15, 2009; 182(8): 4557 - 4564.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. T. Orr, J. C. Sun, D. G.T. Hesslein, H. Arase, J. H. Phillips, T. Takai, and L. L. Lanier
Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection
J. Exp. Med., April 13, 2009; 206(4): 807 - 817.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
F. Tang, Z. Chen, C. Ciszewski, M. Setty, J. Solus, M. Tretiakova, E. Ebert, J. Han, A. Lin, S. Guandalini, et al.
Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15
J. Exp. Med., March 16, 2009; 206(3): 707 - 719.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Krockenberger, Y. Dombrowski, C. Weidler, M. Ossadnik, A. Honig, S. Hausler, H. Voigt, J. C. Becker, L. Leng, A. Steinle, et al.
Macrophage Migration Inhibitory Factor Contributes to the Immune Escape of Ovarian Cancer by Down-Regulating NKG2D
J. Immunol., June 1, 2008; 180(11): 7338 - 7348.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. B. Rosen, W. Cao, D. T. Avery, S. G. Tangye, Y.-J. Liu, J. P. Houchins, and L. L. Lanier
Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells
J. Immunol., May 15, 2008; 180(10): 6508 - 6517.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. D. Coudert, L. Scarpellino, F. Gros, E. Vivier, and W. Held
Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways
Blood, April 1, 2008; 111(7): 3571 - 3578.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Li, B. Ge, M. Nicotra, J. N. H. Stern, H. D. Kopcow, X. Chen, and J. L. Strominger
JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity
PNAS, February 26, 2008; 105(8): 3017 - 3022.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. I. Marusina, S. J. Burgess, I. Pathmanathan, F. Borrego, and J. E. Coligan
Regulation of Human DAP10 Gene Expression in NK and T Cells by Ap-1 Transcription Factors
J. Immunol., January 1, 2008; 180(1): 409 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. H. Carr, D. B. Rosen, H. Arase, D. F. Nixon, J. Michaelsson, and L. L. Lanier
Cutting Edge: KIR3DS1, a Gene Implicated in Resistance to Progression to AIDS, Encodes a DAP12-Associated Receptor Expressed on NK Cells That Triggers NK Cell Activation
J. Immunol., January 15, 2007; 178(2): 647 - 651.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. L. Sutherland, B. Rabinovich, N. J. Chalupny, P. Brawand, R. Miller, and D. Cosman
ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
Blood, August 15, 2006; 108(4): 1313 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
W. Cao, D. B. Rosen, T. Ito, L. Bover, M. Bao, G. Watanabe, Z. Yao, L. Zhang, L. L. Lanier, and Y.-J. Liu
Plasmacytoid dendritic cell-specific receptor ILT7-Fc{varepsilon}RI{gamma} inhibits Toll-like receptor-induced interferon production
J. Exp. Med., June 12, 2006; 203(6): 1399 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
B. Meresse, S. A. Curran, C. Ciszewski, G. Orbelyan, M. Setty, G. Bhagat, L. Lee, M. Tretiakova, C. Semrad, E. Kistner, et al.
Reprogramming of CTLs into natural killer-like cells in celiac disease
J. Exp. Med., May 15, 2006; 203(5): 1343 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Chiesa, M. Mingueneau, N. Fuseri, B. Malissen, D. H. Raulet, M. Malissen, E. Vivier, and E. Tomasello
Multiplicity and plasticity of natural killer cell signaling pathways
Blood, March 15, 2006; 107(6): 2364 - 2372.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Burgess, A. I. Marusina, I. Pathmanathan, F. Borrego, and J. E. Coligan
IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells
J. Immunol., February 1, 2006; 176(3): 1490 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. T. Bryceson, M. E. March, H.-G. Ljunggren, and E. O. Long
Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
Blood, January 1, 2006; 107(1): 159 - 166.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. B. Rosen, J. Bettadapura, M. Alsharifi, P. A. Mathew, H. S. Warren, and L. L. Lanier
Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor
J. Immunol., December 15, 2005; 175(12): 7796 - 7799.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Karimi, T. M. Cao, J. A. Baker, M. R. Verneris, L. Soares, and R. S. Negrin
Silencing Human NKG2D, DAP10, and DAP12 Reduces Cytotoxicity of Activated CD8+ T Cells and NK Cells
J. Immunol., December 15, 2005; 175(12): 7819 - 7828.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. W. L. Teng, M. H. Kershaw, Y. Hayakawa, L. Cerutti, S. M. Jane, P. K. Darcy, and M. J. Smyth
T Cells Gene-engineered with DAP12 Mediate Effector Function in an NKG2D-dependent and Major Histocompatibility Complex-independent Manner
J. Biol. Chem., November 18, 2005; 280(46): 38235 - 38241.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. D. Coudert, J. Zimmer, E. Tomasello, M. Cebecauer, M. Colonna, E. Vivier, and W. Held
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells
Blood, September 1, 2005; 106(5): 1711 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
F. Vely and E. Vivier
Natural Killer Cell Receptor Signaling Pathway in Mammals
Sci. Signal., July 12, 2005; 2005(292): cm7 - cm7.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. D. Huntington, Y. Xu, S. L. Nutt, and D. M. Tarlinton
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
J. Exp. Med., May 2, 2005; 201(9): 1421 - 1433.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Voehringer, D. B. Rosen, L. L. Lanier, and R. M. Locksley
CD200 Receptor Family Members Represent Novel DAP12-associated Activating Receptors on Basophils and Mast Cells
J. Biol. Chem., December 24, 2004; 279(52): 54117 - 54123.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.