The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasaki, Y.
Right arrow Articles by Schmidt-Supprian, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasaki, Y.
Right arrow Articles by Schmidt-Supprian, M.
The Journal of Immunology, 2004, 173: 2245-2252.
Copyright © 2004 by The American Association of Immunologists

TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology1

Yoshiteru Sasaki2,*, Stefano Casola*, Jeffery L. Kutok{dagger}, Klaus Rajewsky* and Marc Schmidt-Supprian2,*

* CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115; and {dagger} Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115

The cytokine TNF family member B cell-activating factor (BAFF; also termed BLyS) is essential for B cell generation and maintenance. Three receptors have been identified that bind to BAFF: transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI); B cell maturation Ag (BCMA); and BAFF-R. Recently, it was shown that A/WySnJ mice, which contain a dramatically reduced peripheral B cell compartment due to decreased B cell life span, express a mutant BAFF-R. This finding, together with normal or enhanced B cell generation in mice deficient for BCMA or TACI, respectively, suggested that the interaction of BAFF with BAFF-R triggers signals essential for the generation and maintenance of mature B cells. However, B cells in mice deficient for BAFF differ phenotypically and functionally from A/WySnJ B cells. Residual signaling through the mutant BAFF-R could account for these differences. Alternatively, dominant-negative interference by the mutant receptor could lead to an overestimation of the importance of BAFF-R. To resolve this issue, we generated BAFF-R-null mice. Baff-r–/– mice display strongly reduced late transitional and follicular B cell numbers and are essentially devoid of marginal zone B cells. Overexpression of Bcl-2 rescues mature B cell development in Baff-r–/– mice, suggesting that BAFF-R mediates a survival signal. CD21 and CD23 surface expression are reduced on mature Baff-r–/– B cells, but not to the same extent as on mature B cells in BAFF-deficient mice. In addition, we found that Baff-r–/– mice mount significant, but reduced, Ag-specific Ab responses and are able to form spontaneous germinal centers in mesenteric lymph nodes. The reduction in Ab titers correlates with the reduced B cell numbers in the mutant mice.


Related articles in The JI:

IN THIS ISSUE

The JI 2004 173: 2209-2210. [Full Text]  



This article has been cited by other articles:


Home page
 Infect. Immun.Home page
C. Tertilt, J. Joh, A. Krause, P. Chou, K. Schneeweiss, R. G. Crystal, and S. Worgall
Expression of B-Cell Activating Factor Enhances Protective Immunity of a Vaccine against Pseudomonas aeruginosa
Infect. Immun., July 1, 2009; 77(7): 3044 - 3055.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
E. Marino, J. Villanueva, S. Walters, D. Liuwantara, F. Mackay, and S. T. Grey
CD4+CD25+ T-Cells Control Autoimmunity in the Absence of B-Cells
Diabetes, July 1, 2009; 58(7): 1568 - 1577.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Castro, J. A. Wright, B. Damdinsuren, K. L. Hoek, G. Carlesso, N. P. Shinners, R. M. Gerstein, R. T. Woodland, R. Sen, and W. N. Khan
B Cell Receptor-Mediated Sustained c-Rel Activation Facilitates Late Transitional B Cell Survival through Control of B Cell Activating Factor Receptor and NF-{kappa}B2
J. Immunol., June 15, 2009; 182(12): 7729 - 7737.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Sarantopoulos, K. E. Stevenson, H. T. Kim, C. S. Cutler, N. S. Bhuiya, M. Schowalter, V. T. Ho, E. P. Alyea, J. Koreth, B. R. Blazar, et al.
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
Blood, April 16, 2009; 113(16): 3865 - 3874.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Hikida, S. Casola, N. Takahashi, T. Kaji, T. Takemori, K. Rajewsky, and T. Kurosaki
PLC-{gamma}2 is essential for formation and maintenance of memory B cells
J. Exp. Med., March 16, 2009; 206(3): 681 - 689.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
U. Salzer, C. Bacchelli, S. Buckridge, Q. Pan-Hammarstrom, S. Jennings, V. Lougaris, A. Bergbreiter, T. Hagena, J. Birmelin, A. Plebani, et al.
Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes
Blood, February 26, 2009; 113(9): 1967 - 1976.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Walters, K. E. Webster, A. Sutherland, S. Gardam, J. Groom, D. Liuwantara, E. Marino, J. Thaxton, A. Weinberg, F. Mackay, et al.
Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses
J. Immunol., January 15, 2009; 182(2): 793 - 801.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. L. Otipoby, Y. Sasaki, M. Schmidt-Supprian, A. Patke, R. Gareus, M. Pasparakis, A. Tarakhovsky, and K. Rajewsky
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells
PNAS, August 26, 2008; 105(34): 12435 - 12438.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Sasaki, D. P. Calado, E. Derudder, B. Zhang, Y. Shimizu, F. Mackay, S.-i. Nishikawa, K. Rajewsky, and M. Schmidt-Supprian
NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells
PNAS, August 5, 2008; 105(31): 10883 - 10888.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kanswal, N. Katsenelson, A. Selvapandiyan, R. J. Bram, and M. Akkoyunlu
Deficient TACI Expression on B Lymphocytes of Newborn Mice Leads to Defective Ig Secretion in Response to BAFF or APRIL
J. Immunol., July 15, 2008; 181(2): 976 - 990.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Y. Shimomura, A. Ogawa, M. Kawada, K. Sugimoto, E. Mizoguchi, H.-N. Shi, S. Pillai, A. K. Bhan, and A. Mizoguchi
A unique B2 B cell subset in the intestine
J. Exp. Med., June 9, 2008; 205(6): 1343 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H.-A Kim, S.-H. Jeon, G.-Y. Seo, J.-B. Park, and P.-H. Kim
TGF-{beta}1 and IFN-{gamma} stimulate mouse macrophages to express BAFF via different signaling pathways
J. Leukoc. Biol., June 1, 2008; 83(6): 1431 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Badr, G. Borhis, E. A. Lefevre, N. Chaoul, F. Deshayes, V. Dessirier, G. Lapree, A. Tsapis, and Y. Richard
BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
Blood, March 1, 2008; 111(5): 2744 - 2754.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. T. Woodland, C. J. Fox, M. R. Schmidt, P. S. Hammerman, J. T. Opferman, S. J. Korsmeyer, D. M. Hilbert, and C. B. Thompson
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
Blood, January 15, 2008; 111(2): 750 - 760.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Darce, B. K. Arendt, X. Wu, and D. F. Jelinek
Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation
J. Immunol., December 1, 2007; 179(11): 7276 - 7286.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. P. Shinners, G. Carlesso, I. Castro, K. L. Hoek, R. A. Corn, R. L. Woodland, M. L. Scott, D. Wang, and W. N. Khan
Bruton's Tyrosine Kinase Mediates NF-{kappa}B Activation and B Cell Survival by B Cell-Activating Factor Receptor of the TNF-R Family
J. Immunol., September 15, 2007; 179(6): 3872 - 3880.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. Debnath, K. M. Roundy, J. J. Weis, and J. H. Weis
Defining In Vivo Transcription Factor Complexes of the Murine CD21 and CD23 Genes
J. Immunol., June 1, 2007; 178(11): 7139 - 7150.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Waisman, M. Kraus, J. Seagal, S. Ghosh, D. Melamed, J. Song, Y. Sasaki, S. Classen, C. Lutz, F. Brombacher, et al.
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig{alpha}/{beta}
J. Exp. Med., April 16, 2007; 204(4): 747 - 758.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Sakurai, H. Hase, Y. Kanno, H. Kojima, K. Okumura, and T. Kobata
TACI regulates IgA production by APRIL in collaboration with HSPG
Blood, April 1, 2007; 109(7): 2961 - 2967.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S. Kothlow, I. Morgenroth, Y. Graef, K. Schneider, I. Riehl, P. Staeheli, P. Schneider, and B. Kaspers
Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken
Int. Immunol., February 1, 2007; 19(2): 203 - 215.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Endo, M. Nishio, T. Enzler, H. B. Cottam, T. Fukuda, D. F. James, M. Karin, and T. J. Kipps
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-{kappa}B pathway
Blood, January 15, 2007; 109(2): 703 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Kato, A. Q. Truong-Tran, A. L. Scott, K. Matsumoto, and R. P. Schleimer
Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-beta-Dependent Mechanism
J. Immunol., November 15, 2006; 177(10): 7164 - 7172.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Patke, I. Mecklenbrauker, H. Erdjument-Bromage, P. Tempst, and A. Tarakhovsky
BAFF controls B cell metabolic fitness through a PKC{beta}- and Akt-dependent mechanism
J. Exp. Med., October 30, 2006; 203(11): 2551 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. O. Jacob, L. Pricop, C. Putterman, M. N. Koss, Y. Liu, M. Kollaros, S. A. Bixler, C. M. Ambrose, M. L. Scott, and W. Stohl
Paucity of Clinical Disease despite Serological Autoimmunity and Kidney Pathology in Lupus-Prone New Zealand Mixed 2328 Mice Deficient in BAFF
J. Immunol., August 15, 2006; 177(4): 2671 - 2680.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Bischof, S. F. Elsawa, G. Mantchev, J. Yoon, G. E. Michels, A. Nilson, S. L. Sutor, J. L. Platt, S. M. Ansell, G. von Bulow, et al.
Selective activation of TACI by syndecan-2
Blood, April 15, 2006; 107(8): 3235 - 3242.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. F. Elsawa, A. J. Novak, D. M. Grote, S. C. Ziesmer, T. E. Witzig, R. A. Kyle, S. R. Dillon, B. Harder, J. A. Gross, and S. M. Ansell
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia
Blood, April 1, 2006; 107(7): 2882 - 2888.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Heltemes-Harris, X. Liu, and T. Manser
An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion
Int. Immunol., November 1, 2005; 17(11): 1447 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Zhang, K.-H. Ko, Q. L. K. Lam, C. K. C. Lo, G. Srivastava, B. Zheng, Y.-L. Lau, and L. Lu
Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis
Int. Immunol., August 1, 2005; 17(8): 1081 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Gavin, B. Duong, P. Skog, D. Ait-Azzouzene, D. R. Greaves, M. L. Scott, and D. Nemazee
{Delta}BAFF, a Splice Isoform of BAFF, Opposes Full-Length BAFF Activity In Vivo in Transgenic Mouse Models
J. Immunol., July 1, 2005; 175(1): 319 - 328.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. P. Sims, R. Ettinger, Y. Shirota, C. H. Yarboro, G. G. Illei, and P. E. Lipsky
Identification and characterization of circulating human transitional B cells
Blood, June 1, 2005; 105(11): 4390 - 4398.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Morrison, W. Reiley, M. Zhang, and S.-C. Sun
An Atypical Tumor Necrosis Factor (TNF) Receptor-associated Factor-binding Motif of B Cell-activating Factor Belonging to the TNF Family (BAFF) Receptor Mediates Induction of the Noncanonical NF-{kappa}B Signaling Pathway
J. Biol. Chem., March 18, 2005; 280(11): 10018 - 10024.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
J T Merrill
BLyS antagonists and peptide tolerance induction
Lupus, March 1, 2005; 14(3): 204 - 209.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
Z. S. M. Rahman and T. Manser
B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers
J. Immunol., November 15, 2004; 173(10): 6179 - 6188.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.