| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
and p110
, in Lymphocyte Chemotaxis and Homing1
* Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143;
Molecular Immunology Programme, The Babraham Institute, Cambridge, United Kingdom;
The 21st Century Center of Excellence Program, Akita University School of Medicine and Precursory Research for Embryonic Science and Technology, Hondo, Akita, Japan;
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria; and
¶
Cell Signalling Group, Ludwig Institute for Cancer Research, and Department of Biochemistry and Molecular Biology, University College, London, United Kingdom.
Despite the established role for PI3Ks in cell migration, the PI3Ks involved in lymphocyte chemotaxis are poorly defined. In this study, we report that p110
-deficient T cells, but not B cells, show reduced chemotactic responses to the lymphoid chemokines, CCL19, CCL21, and CXCL12. As B cell and T cell chemotactic responses were both sensitive to the general PI3K inhibitors, wortmannin (WMN) and LY294002, we explored whether B cell responses were affected in mice lacking p110
, a major PI3K isoform in lymphocytes. B cells deficient in p110 showed diminished chemotactic responses, especially to CXCL13. Adoptive transfer experiments with WMN-treated wild-type B cells and with p110-deficient B cells revealed diminished homing to Peyer’s patches and splenic white pulp cords. WMN selectively inhibited CXCR5-dependent B cell homing to Peyer’s patches. These observations establish that p110 and p110 function in lymphocyte chemotaxis, and show differential roles for PI3K family members in B and T cell migration.
This article has been cited by other articles:
|
|
 |
|
  K. Gollmer, F. Asperti-Boursin, Y. Tanaka, K. Okkenhaug, B. Vanhaesebroeck, J. R. Peterson, Y. Fukui, E. Donnadieu, and J. V. Stein CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway Blood, July 16, 2009; 114(3): 580 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Saudemont, F. Garcon, H. Yadi, M. Roche-Molina, N. Kim, A. Segonds-Pichon, A. Martin-Fontecha, K. Okkenhaug, and F. Colucci p110{gamma} and p110{delta} isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease PNAS, April 7, 2009; 106(14): 5795 - 5800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Matsuda, Y. Mikami, M. Ohtani, M. Fujiwara, Y. Hirata, A. Minowa, Y. Terauchi, T. Kadowaki, and S. Koyasu Critical role of class IA PI3K for c-Rel expression in B lymphocytes Blood, January 29, 2009; 113(5): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Webb, A. Johnson, M. Fortunato, A. Platt, T. Crabbe, M. I. Christie, G. F. Watt, S. G. Ward, and L. A. Jopling Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists J. Leukoc. Biol., October 1, 2008; 84(4): 1202 - 1212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Thomas, J. S. Mitchell, C. C. DeNucci, A. L. Martin, and Y. Shimizu The p110{gamma} isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites J. Leukoc. Biol., September 1, 2008; 84(3): 814 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. J. de Gorter, R. M. Reijmers, E. A. Beuling, H. P. H. Naber, A. Kuil, M. J. Kersten, S. T. Pals, and M. Spaargaren The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells Blood, April 1, 2008; 111(7): 3364 - 3372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fougerat, S. Gayral, P. Gourdy, A. Schambourg, T. Ruckle, M. K. Schwarz, C. Rommel, E. Hirsch, J.-F. Arnal, J.-P. Salles, et al. Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-{gamma} Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes Circulation, March 11, 2008; 117(10): 1310 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Martin, M. D. Schwartz, S. C. Jameson, and Y. Shimizu Selective Regulation of CD8 Effector T Cell Migration by the p110{gamma} Isoform of Phosphatidylinositol 3-Kinase J. Immunol., February 15, 2008; 180(4): 2081 - 2088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Heit, L. Liu, P. Colarusso, K. D. Puri, and P. Kubes PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP J. Cell Sci., January 15, 2008; 121(2): 205 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Janas, D. Hodson, Z. Stamataki, S. Hill, K. Welch, L. Gambardella, L. C. Trotman, P. P. Pandolfi, E. Vigorito, and M. Turner The Effect of Deleting p110{delta} on the Phenotype and Function of PTEN-Deficient B Cells J. Immunol., January 15, 2008; 180(2): 739 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakhaei-Nejad, A. M. Hussain, Q.-X. Zhang, and A. G. Murray Endothelial PI 3-kinase activity regulates lymphocyte diapedesis Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3608 - H3616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Haynes, C. D. C. Allen, R. Lesley, K. M. Ansel, N. Killeen, and J. G. Cyster Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation J. Immunol., October 15, 2007; 179(8): 5099 - 5108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ji, F. Rintelen, C. Waltzinger, D. Bertschy Meier, A. Bilancio, W. Pearce, E. Hirsch, M. P. Wymann, T. Ruckle, M. Camps, et al. Inactivation of PI3K{gamma} and PI3K{delta} distorts T-cell development and causes multiple organ inflammation Blood, October 15, 2007; 110(8): 2940 - 2947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Bach, Q.-M. Chen, W. T. Kerr, Y. Wang, L. Lian, J. K. Choi, D. Wu, M. G. Kazanietz, G. A. Koretzky, S. Zigmond, et al. Phospholipase Cbeta Is Critical for T Cell Chemotaxis J. Immunol., August 15, 2007; 179(4): 2223 - 2227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Matheu, J. A. Deane, I. Parker, D. A. Fruman, and M. D. Cahalan Class IA Phosphoinositide 3-Kinase Modulates Basal Lymphocyte Motility in the Lymph Node J. Immunol., August 15, 2007; 179(4): 2261 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Asperti-Boursin, E. Real, G. Bismuth, A. Trautmann, and E. Donnadieu CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase- independent manner J. Exp. Med., May 14, 2007; 204(5): 1167 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nombela-Arrieta, T. R. Mempel, S. F. Soriano, I. Mazo, M. P. Wymann, E. Hirsch, C. Martinez-A., Y. Fukui, U. H. von Andrian, and J. V. Stein A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress J. Exp. Med., March 19, 2007; 204(3): 497 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Brauweiler, K. Merrell, S. B. Gauld, and J. C. Cambier Cutting Edge: Acute and Chronic Exposure of Immature B Cells to Antigen Leads to Impaired Homing and SHIP1-Dependent Reduction in Stromal Cell-Derived Factor-1 Responsiveness J. Immunol., March 15, 2007; 178(6): 3353 - 3357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Liao, M.-C. Huang, M. Graler, Y. Huang, H. Qiu, and E. J. Goetzl Distinctive T Cell-suppressive Signals from Nuclearized Type 1 Sphingosine 1-Phosphate G Protein-coupled Receptors J. Biol. Chem., January 19, 2007; 282(3): 1964 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Okkenhaug, D. T. Patton, A. Bilancio, F. Garcon, W. C. Rowan, and B. Vanhaesebroeck The p110{delta} Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells J. Immunol., October 15, 2006; 177(8): 5122 - 5128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. B. Hickey and T. G. Cotter BCR-ABL Regulates Phosphatidylinositol 3-Kinase-p110{gamma} Transcription and Activation and Is Required for Proliferation and Drug Resistance J. Biol. Chem., February 3, 2006; 281(5): 2441 - 2450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Yopp, J. C. Ochando, M. Mao, L. Ledgerwood, Y. Ding, and J. S. Bromberg Sphingosine 1-Phosphate Receptors Regulate Chemokine-Driven Transendothelial Migration of Lymph Node but Not Splenic T Cells J. Immunol., September 1, 2005; 175(5): 2913 - 2924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Badr, G. Borhis, D. Treton, and Y. Richard IFN{alpha} enhances human B-cell chemotaxis by modulating ligand-induced chemokine receptor signaling and internalization Int. Immunol., April 1, 2005; 17(4): 459 - 467. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
