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CUTTING EDGE |
and p110
, in Lymphocyte Chemotaxis and Homing1
* Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143;
Molecular Immunology Programme, The Babraham Institute, Cambridge, United Kingdom;
The 21st Century Center of Excellence Program, Akita University School of Medicine and Precursory Research for Embryonic Science and Technology, Hondo, Akita, Japan;
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria; and
¶
Cell Signalling Group, Ludwig Institute for Cancer Research, and Department of Biochemistry and Molecular Biology, University College, London, United Kingdom.
Despite the established role for PI3Ks in cell migration, the PI3Ks involved in lymphocyte chemotaxis are poorly defined. In this study, we report that p110
-deficient T cells, but not B cells, show reduced chemotactic responses to the lymphoid chemokines, CCL19, CCL21, and CXCL12. As B cell and T cell chemotactic responses were both sensitive to the general PI3K inhibitors, wortmannin (WMN) and LY294002, we explored whether B cell responses were affected in mice lacking p110
, a major PI3K isoform in lymphocytes. B cells deficient in p110 showed diminished chemotactic responses, especially to CXCL13. Adoptive transfer experiments with WMN-treated wild-type B cells and with p110-deficient B cells revealed diminished homing to Peyer’s patches and splenic white pulp cords. WMN selectively inhibited CXCR5-dependent B cell homing to Peyer’s patches. These observations establish that p110 and p110 function in lymphocyte chemotaxis, and show differential roles for PI3K family members in B and T cell migration.
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