| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Microbiology and
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242
Substantial CD8+ T cell responses are generated after infection of mice with recombinant Listeria monocytogenes strains expressing a model epitope (lymphocytic choriomeningitis virus NP118–126) in secreted and nonsecreted forms. L. monocytogenes gains access to the cytosol of infected cells, where secreted Ags can be accessed by the endogenous MHC class I presentation pathway. However, the route of presentation of the nonsecreted Ag in vivo remains undefined. In this study we show that neutrophil-enriched peritoneal exudate cells from L. monocytogenes-infected mice can serve as substrates for in vitro cross-presentation of both nonsecreted and secreted Ag by dendritic cells as well as for in vivo cross-priming of CD8+ T cells. In addition, specific neutrophil depletion in vivo by low dose treatment with either of two Ly6G-specific mAb substantially decreased the relative CD8+ T cell response against the nonsecreted, but not the secreted, Ag compared with control Ab-treated mice. Thus, neutrophils not only provide rapid innate defense against infection, but also contribute to shaping the specificity and breadth of the CD8+ T cell response. In addition, cross-presentation of bacterial Ags from neutrophils may explain how CD8+ T cell responses are generated against Ags from extracellular bacterial pathogens.
This article has been cited by other articles:
|
|
 |
|
  N. Kesteman, G. Vansanten, B. Pajak, S. M. Goyert, and M. Moser Injection of lipopolysaccharide induces the migration of splenic neutrophils to the T cell area of the white pulp: role of CD14 and CXC chemokines J. Leukoc. Biol., March 1, 2008; 83(3): 640 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Daley, A. A. Thomay, M. D. Connolly, J. S. Reichner, and J. E. Albina Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice J. Leukoc. Biol., January 1, 2008; 83(1): 64 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. van Faassen, R. KuoLee, G. Harris, X. Zhao, J. W. Conlan, and W. Chen Neutrophils Play an Important Role in Host Resistance to Respiratory Infection with Acinetobacter baumannii in Mice Infect. Immun., December 1, 2007; 75(12): 5597 - 5608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bomfim, B. B. Andrade, S. Santos, J. Clarencio, M. Barral-Netto, and A. Barral Cellular Analysis of Cutaneous Leishmaniasis Lymphadenopathy: Insights into the Early Phases of Human Disease Am J Trop Med Hyg, November 1, 2007; 77(5): 854 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Beauvillain, Y. Delneste, M. Scotet, A. Peres, H. Gascan, P. Guermonprez, V. Barnaba, and P. Jeannin Neutrophils efficiently cross-prime naive T cells in vivo Blood, October 15, 2007; 110(8): 2965 - 2973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ravindran, L. Rusch, A. Itano, M. K. Jenkins, and S. J. McSorley CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection PNAS, July 17, 2007; 104(29): 12075 - 12080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Marks, T. Burns, M. Abadi, B. Seyoum, J. Thornton, E. Tuomanen, and L.-a. Pirofski Influence of Neutropenia on the Course of Serotype 8 Pneumococcal Pneumonia in Mice Infect. Immun., April 1, 2007; 75(4): 1586 - 1597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shiratsuchi, T. Iyoda, N. Tanimoto, D. Kegai, K. Nagata, and Y. Kobayashi Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production J. Leukoc. Biol., February 1, 2007; 81(2): 412 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Pierrot, E. Adam, D. Hot, S. Lafitte, M. Capron, J. D. George, and J. Khalife Contribution of T Cells and Neutrophils in Protection of Young Susceptible Rats from Fatal Experimental Malaria J. Immunol., February 1, 2007; 178(3): 1713 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Seavey and T. R. Mosmann Paternal Antigen-Bearing Cells Transferred during Insemination Do Not Stimulate Anti-Paternal CD8+ T Cells: Role of Estradiol in Locally Inhibiting CD8+ T Cell Responses J. Immunol., December 1, 2006; 177(11): 7567 - 7578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Bahjat, W. Liu, E. E. Lemmens, S. P. Schoenberger, D. A. Portnoy, T. W. Dubensky Jr., and D. G. Brockstedt Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection Infect. Immun., November 1, 2006; 74(11): 6387 - 6397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prickett, P. M. Gray, S. L. Colpitts, P. Scott, P. M. Kaye, and D. F. Smith In vivo recognition of ovalbumin expressed by transgenic leishmania is determined by its subcellular localization. J. Immunol., April 15, 2006; 176(8): 4826 - 4833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Tacke, F. Ginhoux, C. Jakubzick, N. van Rooijen, M. Merad, and G. J. Randolph Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery J. Exp. Med., March 20, 2006; 203(3): 583 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bonneau, M. Epardaud, F. Payot, V. Niborski, M.-I. Thoulouze, F. Bernex, B. Charley, S. Riffault, L. A. Guilloteau, and I. Schwartz-Cornil Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node J. Leukoc. Biol., February 1, 2006; 79(2): 268 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Martinez, M. Vermeulen, A. Trevani, A. Ceballos, J. Sabatte, R. Gamberale, M. E. Alvarez, G. Salamone, T. Tanos, O. A. Coso, et al. Extracellular Acidosis Induces Neutrophil Activation by a Mechanism Dependent on Activation of Phosphatidylinositol 3-Kinase/Akt and ERK Pathways J. Immunol., January 15, 2006; 176(2): 1163 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, M. Zhang, H. Tang, and X. Cao Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines Blood, September 15, 2005; 106(6): 2033 - 2041. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
