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* Multiorgan Transplantation Program, Toronto General Hospital and
Ontario Cancer Institute, University Health Network, Toronto, Canada; and
Departments of Surgery and
Medical Biophysics, University of Toronto, Toronto, Canada
The developmental pathways and differentiation relationship of dendritic cell (DC) subsets remain unclear. We report that murine CD11c+MHC II– bone marrow cells, which are immediate DC precursors of CD8
+, CD8–, and B220+ DC in vivo, can be separated into B220+ and B220– DC precursor subpopulations. Purified B220– DC precursors expand, and generate exclusively mature CD11c+CD11b+B220– DC in vitro and after adoptive transfer. B220+ DC precursors, which resemble plasmacytoid pre-DC, have a lower proliferative potential than B220– DC precursors and generate both CD11b– B220+ and CD11b+B220– DC populations. Both DC precursor populations can give rise to CD8+ and CD8– DC subtypes. Our findings indicate that CD11c+MHC II–B220+ and CD11c+MHC II–B220– bone marrow cells are distinct DC lineage-restricted precursors.
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