| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Fetoprotein Impairs APC Function and Induces Their Apoptosis1
* Institute of Hepatology, University College London, and
Liver Unit, Cromwell Hospital, London, United Kingdom
-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecules and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated DCs produced low levels of IL-12 and TNF-, a cytokine pattern that could hamper an efficient antitumor immune response. Ex vivo, APCs of patients with HCC and high levels of AFP produced lower levels of TNF- than that of healthy individuals. In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control.
This article has been cited by other articles:
|
|
 |
|
  D.-M. Kuang, Q. Zhao, J. Xu, J.-P. Yun, C. Wu, and L. Zheng Tumor-Educated Tolerogenic Dendritic Cells Induce CD3{epsilon} Down-Regulation and Apoptosis of T Cells through Oxygen-Dependent Pathways J. Immunol., September 1, 2008; 181(5): 3089 - 3098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Alisa, S. Boswell, A. A. Pathan, L. Ayaru, R. Williams, and S. Behboudi Human CD4+ T Cells Recognize an Epitope within {alpha}-Fetoprotein Sequence and Develop into TGF-{beta}-Producing CD4+ T Cells J. Immunol., April 1, 2008; 180(7): 5109 - 5117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Wilkinson, W.-W. Tsai, M. A. Schumacher, and M. C. Barton Chromatin-Bound p53 Anchors Activated Smads and the mSin3A Corepressor To Confer Transforming Growth Factor {beta}-Mediated Transcription Repression Mol. Cell. Biol., March 15, 2008; 28(6): 1988 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Mizejewski Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome Experimental Biology and Medicine, September 1, 2007; 232(8): 993 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ayaru, S. P. Pereira, A. Alisa, A. A. Pathan, R. Williams, B. Davidson, A. K. Burroughs, T. Meyer, and S. Behboudi Unmasking of {alpha}-Fetoprotein-Specific CD4+ T Cell Responses in Hepatocellular Carcinoma Patients Undergoing Embolization J. Immunol., February 1, 2007; 178(3): 1914 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Butterfield, A. Ribas, V. B. Dissette, Y. Lee, J. Q. Yang, P. De la Rocha, S. D. Duran, J. Hernandez, E. Seja, D. M. Potter, et al. A Phase I/II Trial Testing Immunization of Hepatocellular Carcinoma Patients with Dendritic Cells Pulsed with Four {alpha}-Fetoprotein Peptides. Clin. Cancer Res., May 1, 2006; 12(9): 2817 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Cui, T. T. Nguyen, J. H. Taube, S. A. Stratton, M. H. Feuerman, and M. C. Barton Family Members p53 and p73 Act Together in Chromatin Modification and Direct Repression of {alpha}-Fetoprotein Transcription J. Biol. Chem., November 25, 2005; 280(47): 39152 - 39160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Alisa, A. Ives, A. A. Pathan, C. V. Navarrete, R. Williams, A. Bertoletti, and S. Behboudi Analysis of CD4+ T-Cell Responses to a Novel {alpha}-Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients Clin. Cancer Res., September 15, 2005; 11(18): 6686 - 6694. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
