The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, K. M.
Right arrow Articles by Garside, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, K. M.
Right arrow Articles by Garside, P.
The Journal of Immunology, 2004, 173: 1640-1646.
Copyright © 2004 by The American Association of Immunologists

In Vivo Generated Th1 Cells Can Migrate to B Cell Follicles to Support B Cell Responses1

Karen M. Smith2, James M. Brewer, Catherine M. Rush, Jillian Riley and Paul Garside

Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, Glasgow, United Kingdom

The description of Th1 and Th2 T cell subsets rationalized the inverse correlation between humoral and cell-mediated immunity. Although Th1 cells were described to support cell-mediated immune responses, their role in supporting certain B cell responses was firmly established. However, there is now a prevailing preconception that provision of B cell help is entirely the domain of Th2 cells and that Th1 cells lack this capacity. Previous studies demonstrated that immunization using aluminum hydroxide adjuvants induces Ag-specific Th2 responses, whereas incorporation of IL-12 with aluminum hydroxide produces a Th1 inducing adjuvant. By immunizing TCR transgenic recipient mice in this fashion, we have generated Ag-specific, traceable Th1 and Th2 cells in vivo and assessed their follicular migration and ability to support B cell responses. In this study we have shown that in vivo polarized Th1 and Th2 cells clonally expand to similar levels and migrate into B cell follicles in which they support B cell responses to a similar degree. Critically, we present direct evidence that in vivo polarized, IFN-{gamma} secreting Th1 cells migrate into B cell follicles where they can interact with Ag-specific B cells.




This article has been cited by other articles:


Home page
 ScienceHome page
R. J. Johnston, A. C. Poholek, D. DiToro, I. Yusuf, D. Eto, B. Barnett, A. L. Dent, J. Craft, and S. Crotty
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Science, August 21, 2009; 325(5943): 1006 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M B Nickdel, P Conigliaro, G Valesini, S Hutchison, R Benson, R V Bundick, A J Leishman, I B McInnes, J M Brewer, and P Garside
Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis
Ann Rheum Dis, June 1, 2009; 68(6): 1059 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Eddahri, S. Denanglaire, F. Bureau, R. Spolski, W. J. Leonard, O. Leo, and F. Andris
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
Blood, March 12, 2009; 113(11): 2426 - 2433.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. M. Morton, B. McManus, P. Garside, A. McI. Mowat, and M. M. Harnett
Inverse Rap1 and Phospho-ERK Expression Discriminate the Maintenance Phase of Tolerance and Priming of Antigen-Specific CD4+ T Cells In Vitro and In Vivo
J. Immunol., December 15, 2007; 179(12): 8026 - 8034.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
M. J. Lodes, H. Secrist, D. R. Benson, S. Jen, K. D. Shanebeck, J. Guderian, J.-F. Maisonneuve, A. Bhatia, D. Persing, S. Patrick, et al.
Variable expression of immunoreactive surface proteins of Propionibacterium acnes
Microbiology, December 1, 2006; 152(12): 3667 - 3681.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. MacLeod, M. J. Kwakkenbos, A. Crawford, S. Brown, B. Stockinger, K. Schepers, T. Schumacher, and D. Gray
CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40
J. Exp. Med., April 17, 2006; 203(4): 897 - 906.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. A. Marshall, A. M. Grierson, P. Garside, W. Harnett, and M. M. Harnett
ES-62, an Immunomodulator Secreted by Filarial Nematodes, Suppresses Clonal Expansion and Modifies Effector Function of Heterologous Antigen-Specific T Cells In Vivo
J. Immunol., November 1, 2005; 175(9): 5817 - 5826.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. L. Fields, S. A. Nish, B. D. Hondowicz, M. H. Metzgar, G. N. Wharton, A. J. Caton, and J. Erikson
The Influence of Effector T Cells and Fas Ligand on Lupus-Associated B Cells
J. Immunol., July 1, 2005; 175(1): 104 - 111.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
B. H. Zinselmeyer, J. Dempster, A. M. Gurney, D. Wokosin, M. Miller, H. Ho, O. R. Millington, K. M. Smith, C. M. Rush, I. Parker, et al.
In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance
J. Exp. Med., June 6, 2005; 201(11): 1815 - 1823.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.