HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Laurent, M. N. Articles by Alberola-Ila, J. Search for Related Content PubMed PubMed Citation Articles by Laurent, M. N. Articles by Alberola-Ila, J. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene

Kinase Suppressor of Ras Couples Ras to the ERK Cascade during T Cell Development

Division of Biology, California Institute of Technology, Pasadena, CA 91125

Ras signaling is critical for many developmental processes and requires the precise coordination of interactions among multiple downstream components. One mechanism by which this regulation is achieved is through the use of scaffolding molecules that coordinate the assembly of multimolecular complexes. Recently, the scaffolding molecule kinase suppressor of Ras (KSR) was isolated in genetic screens as a modifier of Ras signaling, although its contribution to regulating Ras-mediated activation of its different downstream effectors is not well understood. We have analyzed the role of KSR in linking Ras to the ERK cascade during positive selection. Our results demonstrate that KSR overexpression interferes with T cell development, an effect that requires the direct interaction between KSR and MEK. This functional effect correlates with the ability of KSR to uncouple Ras from the ERK cascade when overexpressed.

This article has been cited by other articles:

				J. Lin, A. Harding, E. Giurisato, and A. S. Shaw KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs Mol. Cell. Biol., April 15, 2009; 29(8): 2082 - 2091. [Abstract] [Full Text] [PDF]