The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, C. F.
Right arrow Articles by Mosser, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, C. F.
Right arrow Articles by Mosser, D. M.
The Journal of Immunology, 2004, 173: 955-961.
Copyright © 2004 by The American Association of Immunologists

T Cell Biasing by Activated Dendritic Cells1

Charles F. Anderson2, Mark Lucas, Laila Gutiérrez-Kobeh3, Ann E. Field and David M. Mosser4

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742

We have previously reported that the ligation of Fc{gamma}Rs on activated macrophages affected their production of cytokines and their ability to influence T cell activation. Dendritic cells (DC) are important APCs that also express Fc{gamma}R. In the present work, we sought to determine whether DC responded to immune complexes in a manner similar to macrophages. We confirmed that activated murine DC produced IL-12, and, as a result, induced naive T cells to produce primarily IFN-{gamma} upon stimulation. However, DC activated in the presence of immune complexes shut off their production of IL-12p70 and induced a Th2-like cytokine response. Thus, DC respond to immune complexes by altering their cytokine production, which, in turn, influences T cell responses. A DC transfer experiment was performed to determine the extent that APC exposure to immune complexes could influence adaptive immune responses. Vaccination of mice with Ag, along with DC that were activated in the presence of immune complexes, resulted in higher levels of Ag-specific IgG1 Ab, relative to mice that were vaccinated with activated DC and Ag alone. The mechanism by which DC altered their cytokine production in response to immune complexes was different from macrophages. Macrophages down-regulated the transcription of both the p40 and p35 subunits of IL-12, whereas DC decreased only p35 expression. We conclude that APCs expressing Fc{gamma}R on their surface can respond to immune complexes by shutting off IL-12 biosynthesis, to prevent the Th1-type T cell biasing that normally accompanies innate immune activation.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. A. Vargas-Inchaustegui, L. Xin, and L. Soong
Leishmania braziliensis Infection Induces Dendritic Cell Activation, ISG15 Transcription, and the Generation of Protective Immune Responses
J. Immunol., June 1, 2008; 180(11): 7537 - 7545.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. S. Bandukwala, B. S. Clay, J. Tong, P. D. Mody, J. L. Cannon, R. A. Shilling, J. S. Verbeek, J. V. Weinstock, J. Solway, and A. I. Sperling
Signaling through Fc{gamma}RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation
J. Exp. Med., August 6, 2007; 204(8): 1875 - 1889.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. E. Field, S. Wagage, S. M. Conrad, and D. M. Mosser
Reduced Pathology following Infection with Transgenic Leishmania major Expressing Murine CD40 Ligand
Infect. Immun., June 1, 2007; 75(6): 3140 - 3149.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Thomas-Rudolph, T. W. Du Clos, C. M. Snapper, and C. Mold
C-Reactive Protein Enhances Immunity to Streptococcus pneumoniae by Targeting Uptake to Fc{gamma}R on Dendritic Cells
J. Immunol., June 1, 2007; 178(11): 7283 - 7291.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. D. Desai, S. O. Harbers, M. Flores, L. Colonna, M. P. Downie, A. Bergtold, S. Jung, and R. Clynes
Fc{gamma} Receptor IIB on Dendritic Cells Enforces Peripheral Tolerance by Inhibiting Effector T Cell Responses
J. Immunol., May 15, 2007; 178(10): 6217 - 6226.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. Prehn, L. S. Thomas, C. J. Landers, Q. T. Yu, K. S. Michelsen, and S. R. Targan
The T Cell Costimulator TL1A Is Induced by Fc{gamma}R Signaling in Human Monocytes and Dendritic Cells
J. Immunol., April 1, 2007; 178(7): 4033 - 4038.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Sironi, F. O. Martinez, D. D'Ambrosio, M. Gattorno, N. Polentarutti, M. Locati, A. Gregorio, A. Iellem, M. A. Cassatella, J. Van Damme, et al.
Differential regulation of chemokine production by Fc{gamma} receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2)
J. Leukoc. Biol., August 1, 2006; 80(2): 342 - 349.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A G Pockley and J Frostegard
Heat shock proteins in cardiovascular disease and the prognostic value of heat shock protein related measurements
Heart, September 1, 2005; 91(9): 1124 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. A. Miles, S. M. Conrad, R. G. Alves, S. M.B. Jeronimo, and D. M. Mosser
A role for IgG immune complexes during infection with the intracellular pathogen Leishmania
J. Exp. Med., March 7, 2005; 201(5): 747 - 754.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.