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The Journal of Immunology, 2004, 173: 7259-7268.
Copyright © 2004 by The American Association of Immunologists

CD25– T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion1

Maria A. Curotto de Lafaille2, Andreia C. Lino, Nino Kutchukhidze and Juan J. Lafaille2

Molecular Pathogenesis Program, Skirball Institute, and Department of Pathology, New York University School of Medicine, New York, NY 10016

Naturally occurring CD4+ regulatory T cells are generally identified through their expression of CD25. However, in several experimental systems considerable Treg activity has been observed in the CD4+CD25– fraction. Upon adoptive transfer, the expression of CD25 in donor-derived cells is not stable, with CD4+CD25+ cells appearing in CD4+CD25– T cell-injected animals and vice versa. We show in this study that CD25+ cells arising from donor CD25– cells upon homeostatic proliferation in recipient mice express markers of freshly isolated Treg cells, display an anergic state, and suppress the proliferation of other cells in vitro. The maintenance of CD25 expression by CD4+CD25+ cells depends on IL-2 secreted by cotransferred CD4+CD25– or by Ag-stimulated T cells in peripheral lymphoid organs.




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