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* Molecular Biology Laboratory, Alliance for Cellular Signaling, Division of Biology, California Institute of Technology, Pasadena, CA 91125;
Bioinformatics and Data Coordination Laboratory, Alliance for Cellular Signaling, San Diego Supercomputer Center, and
Department of Bioengineering, University of California, San Diego, CA 92122;
Cell Preparation and Analysis Laboratory, Alliance for Cellular Signaling, Department of Pharmacology, and
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Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390;
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Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697; and
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Macrophage Biology Laboratory, Alliance for Cellular Signaling, Department of Medicine, University of California, San Francisco, CA 94143
We examined the major patterns of changes in gene expression in mouse splenic B cells in response to stimulation with 33 single ligands for 0.5, 1, 2, and 4 h. We found that ligands known to directly induce or costimulate proliferation, namely, anti-IgM (anti-Ig), anti-CD40 (CD40L), LPS, and, to a lesser extent, IL-4 and CpG-oligodeoxynucleotide (CpG), induced significant expression changes in a large number of genes. The remaining 28 single ligands produced changes in relatively few genes, even though they elicited measurable elevations in intracellular Ca2+ and cAMP concentration and/or protein phosphorylation, including cytokines, chemokines, and other ligands that interact with G protein-coupled receptors. A detailed comparison of gene expression responses to anti-Ig, CD40L, LPS, IL-4, and CpG indicates that while many genes had similar temporal patterns of change in expression in response to these ligands, subsets of genes showed unique expression patterns in response to IL-4, anti-Ig, and CD40L.
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