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The Journal of Immunology, 2004, 173: 7109-7113.
Copyright © 2004 by The American Association of Immunologists

BRIEF REVIEWS

Notch Governing Mature T Cell Differentiation

Shin-ichi Tsukumo and Koji Yasutomo1

Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan

The differentiation of naive T cells to effector/memory T cells is regulated by a variety of factors. The recent advance of the contribution of Notch signaling in this differentiation step has provided a new path to better understand the acquisition or persistence of effector function of mature T cells. In this review, we summarize emerging and, in some points, conflicting evidence for Notch signaling on mature T cell activation and differentiation.




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