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B Activation in Airways Modulates Allergic Inflammation but Not Hyperresponsiveness1
,
* Vermont Lung Center and the Department of Medicine, Division of Pulmonary and Critical Care,
Department of Pathology, and
Department of Medical Biostatistics, University of Vermont, Burlington, VT 05405
Airways display robust NF-
B activation and represent targets for anti-inflammatory asthma therapies, but the functional importance of NF-B activation in airway epithelium remains enigmatic. Therefore, transgenic mice were created in which NF-B activation is repressed specifically in airways (CC10-IB
SR mice). In response to inhaled Ag, transgenic mice demonstrated significantly ameliorated inflammation, reduced levels of chemokines, T cell cytokines, mucus cell metaplasia, and circulating IgE compared with littermate controls. Despite these findings, Ag-driven airways hyperresponsiveness was not attenuated in CC10-IBSR mice. This study clearly demonstrates that airway epithelial NF-B activation orchestrates Ag-induced inflammation and subsequent adaptive immune responses, but does not contribute to airways hyperresponsiveness, the cardinal feature that underlies asthma.
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