| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109; and
Children’s Hospital, Harvard Medical School, Boston, MA 02115
CCR1 has previously been shown to play important roles in leukocyte trafficking, pathogen clearance, and the type 1/type 2 cytokine balance, although very little is known about its role in the host response during sepsis. In a cecal ligation and puncture model of septic peritonitis, CCR1-deficient (CCR1–/–) mice were significantly protected from the lethal effects of sepsis when compared with wild-type (WT) controls. The peritoneal and systemic cytokine profile in CCR1–/– mice was characterized by a robust, but short-lived and regulated antibacterial response. CCR1 expression was not required for leukocyte recruitment, suggesting critical differences extant in the activation of WT and CCR1–/– resident or recruited peritoneal cells during sepsis. Peritoneal macrophages isolated from naive CCR1–/– mice clearly demonstrated enhanced cytokine/chemokine generation and antibacterial responses compared with similarly treated WT macrophages. CCR1 and CCL5 interactions markedly altered the inflammatory response in vivo and in vitro. Administration of CCL5 increased sepsis-induced lethality in WT mice, whereas neutralization of CCL5 improved survival. CCL5 acted in a CCR1-dependent manner to augment production of IFN-
and MIP-2 to damaging levels. These data illustrate that the interaction between CCR1 and CCL5 modulates the innate immune response during sepsis, and both represent potential targets for therapeutic intervention.
This article has been cited by other articles:
|
|
 |
|
  U. Diczfalusy, K. E. Olofsson, A.-M. Carlsson, M. Gong, D. T. Golenbock, O. Rooyackers, U. Flaring, and H. Bjorkbacka Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide J. Lipid Res., November 1, 2009; 50(11): 2258 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-T. Nguyen, S.-A Ju, S.-M. Park, S.-C. Lee, H. Yagita, I. H. Lee, and B.-S. Kim Blockade of CD137 Signaling Counteracts Polymicrobial Sepsis Induced by Cecal Ligation and Puncture Infect. Immun., September 1, 2009; 77(9): 3932 - 3938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Thio, J. Astemborski, R. Thomas, T. Mosbruger, M. D. Witt, J. J. Goedert, K. Hoots, C. Winkler, D. L. Thomas, and M. Carrington Interaction between RANTES Promoter Variant and CCR5{Delta}32 Favors Recovery from Hepatitis B J. Immunol., December 1, 2008; 181(11): 7944 - 7947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishida, T. Hayashi, T. Goto, A. Kimura, S. Akimoto, N. Mukaida, and T. Kondo Essential Involvement of CX3CR1-Mediated Signals in the Bactericidal Host Defense during Septic Peritonitis J. Immunol., September 15, 2008; 181(6): 4208 - 4218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Joshi, T. Raymond, A. L. Coelho, S. L. Kunkel, and C. M. Hogaboam A systemic granulomatous response to Schistosoma mansoni eggs alters responsiveness of bone marrow-derived macrophages to Toll-like receptor agonists J. Leukoc. Biol., February 1, 2008; 83(2): 314 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Schaller, L. E. Kallal, and N. W. Lukacs A Key Role for CC Chemokine Receptor 1 in T-Cell-Mediated Respiratory Inflammation Am. J. Pathol., February 1, 2008; 172(2): 386 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Choi, G. C. Hildebrandt, K. M. Olkiewicz, D. A. Hanauer, M. N. Chaudhary, I. A. Silva, C. E. Rogers, D. T. Deurloo, J. M. Fisher, C. Liu, et al. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation Blood, November 1, 2007; 110(9): 3447 - 3455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Coelho, M. A. Schaller, C. F. Benjamim, A. Z. Orlofsky, C. M. Hogaboam, and S. L. Kunkel The Chemokine CCL6 Promotes Innate Immunity via Immune Cell Activation and Recruitment J. Immunol., October 15, 2007; 179(8): 5474 - 5482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hegde, H. Zhang, S. M. Moochhala, and M. Bhatia Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis J. Leukoc. Biol., September 1, 2007; 82(3): 678 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. He, R. Horuk, S. M. Moochhala, and M. Bhatia Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1173 - G1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Keepers, L. K. Gross, and T. G. Obrig Monocyte Chemoattractant Protein 1, Macrophage Inflammatory Protein 1{alpha}, and RANTES Recruit Macrophages to the Kidney in a Mouse Model of Hemolytic-Uremic Syndrome Infect. Immun., March 1, 2007; 75(3): 1229 - 1236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Ness, J. L. Ewing, C. M. Hogaboam, and S. L. Kunkel CCR4 Is a Key Modulator of Innate Immune Responses J. Immunol., December 1, 2006; 177(11): 7531 - 7539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Moreno, J. C. Alves-Filho, F. Rios-Santos, J. S. Silva, S. H. Ferreira, F. Q. Cunha, and M. M. Teixeira Signaling via Platelet-Activating Factor Receptors Accounts for the Impairment of Neutrophil Migration in Polymicrobial Sepsis J. Immunol., July 15, 2006; 177(2): 1264 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Carpenter and C. M. Hogaboam Immunosuppressive Effects of CCL17 on Pulmonary Antifungal Responses during Pulmonary Invasive Aspergillosis Infect. Immun., November 1, 2005; 73(11): 7198 - 7207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Reiley, M. Zhang, X. Wu, E. Granger, and S.-C. Sun Regulation of the Deubiquitinating Enzyme CYLD by I{kappa}B Kinase Gamma-Dependent Phosphorylation Mol. Cell. Biol., May 15, 2005; 25(10): 3886 - 3895. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
