| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunohematology and Blood Transfusion and
Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Killer Ig-like receptors (KIR) are commonly found on human NK cells, 
T cells, and CD8 T cells. Although KIR+ CD4 T cells are found in certain patients, their prevalence in healthy donors is controversial. We now provide definitive proof that such cells are present in most individuals, and report on their frequency, surface phenotype, cytokine profile, and Ag specificity. The number of KIR+ CD4 T cells detected in peripheral blood increased with age. In contrast with regular KIR– CD4 T cells, the majority of KIR+ CD4 T cells lacked surface expression of CD27, CD28, CCR4, and CCR7, but did express CD57 and 2B4. In addition, KIR were detected on approximately one-tenth of CD28– and CD57+ memory CD4 T cells. In line with the absence of the Th2 marker CCR4, the KIR+ CD4 cells produced mainly IFN- and little IL-4, IL-10, or IL-17 upon TCR triggering. Furthermore, the KIR+ population contained cells that responded to recall Ags in an HLA class II-restricted fashion. Together, our data indicate that KIR-expressing CD4 T cells are predominantly HLA class II-restricted effector memory Th1 cells, and that a significant, previously unrecognized fraction of effector memory Th1 cells expresses KIR.
This article has been cited by other articles:
|
|
 |
|
  G. Li, M. Yu, C. M. Weyand, and J. J. Goronzy Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells Blood, October 15, 2009; 114(16): 3422 - 3430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. van Bergen, E. M. C. Kooy-Winkelaar, H. van Dongen, F. A. van Gaalen, A. Thompson, T. W. J. Huizinga, M. C. W. Feltkamp, R. E. M. Toes, and F. Koning Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus J. Immunol., April 1, 2009; 182(7): 4175 - 4182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. van der Veken, M. Diez Campelo, M. A. W. G. van der Hoorn, R. S. Hagedoorn, H. M. E. van Egmond, J. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. H. M. Heemskerk Functional Analysis of Killer Ig-Like Receptor-Expressing Cytomegalovirus-Specific CD8+ T Cells J. Immunol., January 1, 2009; 182(1): 92 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Merck, R. B. Voyle, and H. R. MacDonald Ly49D Engagement on T Lymphocytes Induces TCR-Independent Activation and CD8 Effector Functions That Control Tumor Growth J. Immunol., January 1, 2009; 182(1): 183 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Fourmentraux-Neves, A. Jalil, S. Da Rocha, C. Pichon, S. Chouaib, G. Bismuth, and A. Caignard Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells Blood, September 15, 2008; 112(6): 2381 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, C. M. Weyand, and J. J. Goronzy Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells J. Leukoc. Biol., September 1, 2008; 84(3): 824 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Yamada, Y Nakashima, K Okazaki, T Mawatari, J-I Fukushi, N Kaibara, A Hori, Y Iwamoto, and Y Yoshikai Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis Ann Rheum Dis, September 1, 2008; 67(9): 1299 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Larbi, C. Franceschi, D. Mazzatti, R. Solana, A. Wikby, and G. Pawelec Aging of the Immune System as a Prognostic Factor for Human Longevity Physiology, April 1, 2008; 23(2): 64 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Remtoula, A. Bensussan, and A. Marie-Cardine Cutting Edge: Selective Expression of Inhibitory or Activating Killer Cell Ig-Like Receptors in Circulating CD4+ T Lymphocytes J. Immunol., March 1, 2008; 180(5): 2767 - 2771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Lemster, J. J. Michel, D. T. Montag, J. J. Paat, S. A. Studenski, A. B. Newman, and A. N. Vallejo Induction of CD56 and TCR-Independent Activation of T Cells with Aging J. Immunol., February 1, 2008; 180(3): 1979 - 1990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Santourlidis, N. Graffmann, J. Christ, and M. Uhrberg Lineage-Specific Transition of Histone Signatures in the Killer Cell Ig-Like Receptor Locus from Hematopoietic Progenitor to NK Cells J. Immunol., January 1, 2008; 180(1): 418 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Iliopoulou, M. V. Karamouzis, I. Missitzis, A. Ardavanis, N. N. Sotiriadou, C. N. Baxevanis, G. Rigatos, M. Papamichail, and S. A. Perez Increased Frequency of CD4+ Cells Expressing CD161 in Cancer Patients Clin. Cancer Res., December 1, 2006; 12(23): 6901 - 6909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. M. van Leeuwen, E. B. M. Remmerswaal, M. H. M. Heemskerk, I. J. M. ten Berge, and R. A. W. van Lier Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection Blood, November 1, 2006; 108(9): 3121 - 3127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cook, D. Briggs, C. Craddock, P. Mahendra, D. Milligan, C. Fegan, P. Darbyshire, S. Lawson, E. Boxall, and P. Moss Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation Blood, February 1, 2006; 107(3): 1230 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Williams, A. R. Bateman, and S. I. Khakoo HANGING IN THE BALANCE: KIR and Their Role in Disease Mol. Interv., August 1, 2005; 5(4): 226 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, A. N. Vallejo, Y. Jiang, C. M. Weyand, and J. J. Goronzy Distinct Transcriptional Control Mechanisms of Killer Immunoglobulin-like Receptors in Natural Killer (NK) and in T Cells J. Biol. Chem., June 24, 2005; 280(25): 24277 - 24285. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
