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IL-19 Induced Th2 Cytokines and Was Up-Regulated in Asthma Patients¹

Sheng-Chin Liao^*, Yung-Chih Cheng^*, Yo-Ching Wang^*, Chiung-Wen Wang^*, San-Ming Yang^*, Chun-Keung Yu, Chi-Chang Shieh, Kuo-Chen Cheng, Meng-Feng Lee, Shyh-Ren Chiang, Jiunn-Min Shieh and Ming-Shi Chang^2,*,

^* Graduate Institute of Biochemistry and Graduate Institute of Microbiology and Immunology Medical College, National Cheng Kung University, Tainan, Taiwan; and Chi-Mei Medical Center, Tainan, Taiwan

IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene-7 (IL-24), and AK155 (IL-26). IL-10 has been shown to inhibit allergen-induced airway hyperreactivity and inflammation. To determine whether IL-19 was also associated with asthma, we used ELISA to analyze the serum level of IL-19 in patients with asthma and found that their serum IL-19 levels were twice those of healthy controls. Patients with a high level of IL-19 also had high levels of IL-4 and IL-13. In a dust mite-induced murine model of asthma, we found that IL-19 level in asthmatic BALB/cJ mice was also twice that of healthy control mice. IL-19 transcript was also induced in the lungs of asthmatic mice. Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. However, IL-19 up-regulated IL-13 in asthmatic mice. In vitro, IL-19 induced IL-4, IL-5, IL-10, and IL-13 production by activated T cells. Activation of T cells was required for induction of IL-13 because IL-19 did not induce IL-13 production on nonstimulated T cells. Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma.

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The JI 2004 173: 6499-6500. [Full Text]  

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