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CUTTING EDGE |
Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells1
* I. Medizinische Klinik,
Institut für Pathologie,
Naturwissenschaftlich-Medizinisches Forschungszentrum, Johannes Gutenberg-Universität, Mainz, Germany; and
Biotechnologisch Biomedizinisches Zentrum, Universität Leipzig, Leipzig, Germany
Data regarding the role of TGF-
for the in vivo function of regulatory CD4+CD25+ T cells (Treg) are controversial. A transgenic mouse model with impaired TGF- signaling specifically in T cells was used to assess the role of endogenous TGF- for the in vivo function of CD4+CD25+ Treg in a murine model of colitis induced by dextran sulfate. Transfer of wild-type, but not transgenic CD4+CD25+ Treg was found to suppress colitis in wild-type mice. In addition, by transferring CFSE-labeled CD4+CD25+ Treg we could demonstrate that endogenous TGF- promotes the expansion of CD4+CD25+ Treg in vivo. Transgenic mice themselves developed reduced numbers of peripheral CD4+CD25+ Treg and were more susceptible to the induction of colitis, which could be prevented by the transfer of wild-type Treg. These data indicate that TGF- signaling in CD4+CD25+ Treg is required for their in vivo expansion and suppressive capacity.
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