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The Journal of Immunology, 2004, 173: 6515-6520.
Copyright © 2004 by The American Association of Immunologists

BRIEF REVIEWS

The Fourth Way? Harnessing Aggressive Tendencies in the Thymus1

Troy A. Baldwin, Kristin A. Hogquist and Stephen C. Jameson2

Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455

During late stages of thymic development, T cells must chose between different fates, dictated by their TCR specificity. Typically, this is thought of as a choice between three alternatives (being positive selection for useful T cells vs negative selection or neglect for harmful or useless T cells). However, there is growing evidence for a fourth alternative, in which T cells are positively selected by agonist ligands, which would normally be expected to induce T cell deletion. In this review, we will discuss where and when agonist selection is induced and whether this should be considered as a novel form of thymic selection or as an alternative differentiation state for Ag-exposed T cells.




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