The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldberg, R.
Right arrow Articles by Karin, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldberg, R.
Right arrow Articles by Karin, N.
The Journal of Immunology, 2004, 173: 6465-6471.
Copyright © 2004 by The American Association of Immunologists

Suppression of Ongoing Experimental Autoimmune Encephalomyelitis by Neutralizing the Function of the p28 Subunit of IL-271

Ruth Goldberg*,{ddagger}, Yaniv Zohar*, Gizi Wildbaum*, Yifat Geron*, Gila Maor{ddagger} and Nathan Karin2,*,{dagger}

* Department of Immunology, {dagger} Rappaport Family Institute for Research in the Medical Sciences, and {ddagger} Department of Morphological Sciences, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

IL-27 is a recently defined family member of the long-chain, four-helix bundle cytokines, which consist of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related polypeptide. The role of IL-27 in the regulation of experimental autoimmune encephalomyelitis has never been studied. We show in this study that neutralizing the in vivo function of IL-27 by Abs against IL-27 p28 rapidly suppressed an ongoing long-lasting disease in C57BL/6 mice. These Abs were then used to determine the mechanistic basis of disease suppression. We show in this study that IL-27 is involved not only in the polarization of naive T cells undergoing Ag-specific T cell activation, but also in promoting the proliferation and IFN-{gamma} production by polarized T cells, including the long term Th1 line that has been previously selected against the target encephalitogenic determinant. This may explain in part why neutralizing IL-27 suppresses an already established disease in a very rapid and significant manner.




This article has been cited by other articles:


Home page
 JEMHome page
M. Meiron, Y. Zohar, R. Anunu, G. Wildbaum, and N. Karin
CXCL12 (SDF-1{alpha}) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells
J. Exp. Med., October 27, 2008; 205(11): 2643 - 2655.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
W Niedbala, B Cai, X Wei, A Patakas, B P Leung, I B McInnes, and F Y Liew
Interleukin 27 attenuates collagen-induced arthritis
Ann Rheum Dis, October 1, 2008; 67(10): 1474 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
V. Paunovic, H. P. Carroll, K. Vandenbroeck, and M. Gadina
Signalling, inflammation and arthritis: Crossed signals: the role of interleukin (IL)-12, -17, -23 and -27 in autoimmunity
Rheumatology, June 1, 2008; 47(6): 771 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Xu and P. D. Drew
Peroxisome Proliferator-Activated Receptor-{gamma} Agonists Suppress the Production of IL-12 Family Cytokines by Activated Glia
J. Immunol., February 1, 2007; 178(3): 1904 - 1913.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Schif-Zuck, G. Wildbaum, and N. Karin
Coadministration of Plasmid DNA Constructs Encoding an Encephalitogenic Determinant and IL-10 Elicits Regulatory T Cell-Mediated Protective Immunity in the Central Nervous System
J. Immunol., December 1, 2006; 177(11): 8241 - 8247.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Yoshimura, A. Takeda, S. Hamano, Y. Miyazaki, I. Kinjyo, T. Ishibashi, A. Yoshimura, and H. Yoshida
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism
J. Immunol., October 15, 2006; 177(8): 5377 - 5385.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Larousserie, P. Charlot, E. Bardel, J. Froger, R. A. Kastelein, and O. Devergne
Differential Effects of IL-27 on Human B Cell Subsets
J. Immunol., May 15, 2006; 176(10): 5890 - 5897.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Marusic, M. W. Leach, J. W. Pelker, M. L. Azoitei, N. Uozumi, J. Cui, M. W.H. Shen, C. M. DeClercq, J. S. Miyashiro, B. A. Carito, et al.
Cytosolic phospholipase A2{alpha}-deficient mice are resistant to experimental autoimmune encephalomyelitis
J. Exp. Med., September 19, 2005; 202(6): 841 - 851.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Kimura, S.-C. Tzou, R. Rocchi, M. Kimura, K. Suzuki, A. F. Parlow, N. R. Rose, and P. Caturegli
Interleukin (IL)-12-Driven Primary Hypothyroidism: the Contrasting Roles of Two Th1 Cytokines (IL-12 and Interferon-{gamma})
Endocrinology, August 1, 2005; 146(8): 3642 - 3651.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Schif-Zuck, J. Westermann, N. Netzer, Y. Zohar, M. Meiron, G. Wildbaum, and N. Karin
Targeted Overexpression of IL-18 Binding Protein at the Central Nervous System Overrides Flexibility in Functional Polarization of Antigen-Specific Th2 Cells
J. Immunol., April 1, 2005; 174(7): 4307 - 4315.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2004 by The American Association of Immunologists, Inc. All rights reserved.