| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells1
,
* Department of Molecular Oncology, Graduate School of Medicine and
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan;
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan; and
Department of Immunology, Nagoya University School of Medicine, Nagoya, Japan
The homeostasis of memory CD8+ T cells is regulated by cytokines. IL-15 is shown to promote the proliferation of memory CD8+ T cells, while IL-2 suppresses their division in vivo. This inhibitory effect of IL-2 appears to occur indirectly, through other cell populations including CD25+CD4+ T cells; however, the details of this mechanism remain unclear. In this study, we show that 1) both Ag-experienced and memory phenotype CD8+ T cells divided after the depletion of IL-2 in vivo; 2) this division occurred normally and CD44highIL-2/15R
high CD8+ T cells generated after IL-2 depletion in IL-15 knockout (KO) and in IL-7-depleted IL-15 KO mice; 3) surprisingly, the blockade of IL-2/15R signaling in IL-2-depleted IL-15 KO mice completely abolished the division of memory CD8+ T cells, although the only cytokines known to act through IL-2/15R are IL-2 and IL-15; and 4) the expression of IL-2/15R molecules on memory CD8+ T cells was required for their division induced by IL-2 depletion. These results demonstrate that the depletion of IL-2 in vivo induced memory CD8+ T cell division by an IL-15-independent but by an IL-2/15R-dependent mechanism, suggesting the existence of a novel IL-2/15R-utilizing cytokine that acts directly on memory CD8+ T cells to promote cell division.
This article has been cited by other articles:
|
|
 |
|
  G.-H. Jin, T. Hirano, and M. Murakami Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation Int. Immunol., June 1, 2008; 20(6): 783 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mostbock, M. E. C. Lutsiak, D. E. Milenic, K. Baidoo, J. Schlom, and H. Sabzevari IL-2/Anti-IL-2 Antibody Complex Enhances Vaccine-Mediated Antigen-Specific CD8+ T Cell Responses and Increases the Ratio of Effector/Memory CD8+ T Cells to Regulatory T Cells J. Immunol., April 1, 2008; 180(7): 5118 - 5129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kamimura and M. J. Bevan Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo J. Exp. Med., August 6, 2007; 204(8): 1803 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tanaka, S. Sawamura, T. Satoh, K. Kobayashi, and S. Noda Role of the Indigenous Microbiota in Maintaining the Virus-Specific CD8 Memory T Cells in the Lung of Mice Infected with Murine Cytomegalovirus J. Immunol., April 15, 2007; 178(8): 5209 - 5216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ueda, H. Kuki, D. Kamimura, S. Sawa, K. Seino, T. Tashiro, K.-i. Fushuku, M. Taniguchi, T. Hirano, and M. Murakami CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8+ T cells in a manner dependent on IL-4 Int. Immunol., September 1, 2006; 18(9): 1397 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kamimura, Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb J. Immunol., July 1, 2006; 177(1): 306 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Boyman, M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes Science, March 31, 2006; 311(5769): 1924 - 1927. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
