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The Journal of Immunology, 2004, 173: 5918-5922.
Copyright © 2004 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Immunity and IFN-{gamma} Production during Listeria monocytogenes Infection in the Absence of T-bet1

Sing Sing Way* and Christopher B. Wilson2,*,{dagger}

Departments of * Pediatrics and {dagger} Immunology, University of Washington School of Medicine, Seattle, WA 98195

The T-box transcription factor T-bet is an important regulator of IFN-{gamma} production in all cell types and is considered to be essential for the generation of CD4 Th1 T cells. IFN-{gamma} in turn plays a critical role in immunity to many infectious agents. In this study, we demonstrate that T-bet is not required for host resistance to primary Listeria monocytogenes (LM) infection. In the innate immune phase, control of LM replication, serum IFN-{gamma}, and numbers of IFN-{gamma}-producing NK cells were similar in T-bet-deficient and control mice. In the adaptive immune phase, there was no defect in bacterial clearance or in the numbers of LM-specific IFN-{gamma}-producing CD8 T cells in T-bet-deficient mice and only a modest, although significant, reduction in the numbers of Th1 CD4 T cells and IFN-{gamma} secretion by CD4 T cells. Thus, host resistance and the generation of IFN-{gamma}-producing cells in response to LM infection are not substantially compromised in the absence of T-bet.




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