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Lymphotoxin and TNF Produced by B Cells Are Dispensable for Maintenance of the Follicle-Associated Epithelium but Are Required for Development of Lymphoid Follicles in the Peyer’s Patches ^1,2

Alexei V. Tumanov^*,, Dmitry V. Kuprash, Julie A. Mach^*, Sergei A. Nedospasov^, and Alexander V. Chervonsky^3,*

^* The Jackson Laboratory, Bar Harbor, ME 04609; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; and Basic Research Program, SAIC Frederick, Inc. and Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute, Frederick. MD 21702

Organogenesis of Peyer‘s patches (PP), follicle-associated epithelium, and M cells is impaired in mice lacking B cells. At the same time, lymphotoxin (LT) and TNF are known to be critical for the development of PP. To directly address the function of LT and TNF expressed by B cells in the maintenance of PP structure, we studied the de novo formation of PP in B cell-deficient mice after the transfer of bone marrow from mice with targeted mutations in LT, TNF, or their combinations. We found that although the compartmentalization of T and B cell zones and development of follicular dendritic cells were affected by the lack of B cell-derived LT and TNF, the development of follicle-associated epithelium and M cells in PP was completely independent of LT/TNF production by B cells.

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