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Differences in Signaling Molecule Organization between Naive and Memory CD4⁺ T Lymphocytes ¹

Andrew R. O. Watson^* and William T. Lee^2,*,

^* Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12201-0509; and Laboratory of Clinical and Experimental Immunology and Endocrinology, The Wadsworth Center, Albany, NY 12201-2002

The immunological synapse is a highly organized complex formed at the junction between Ag-specific T cells and APCs as a prelude to cell activation. Although its exact role in modulating T cell signaling is unknown, it is commonly believed that the immunological synapse is the site of cross-talk between the T cell and APC (or target). We have examined the synapses formed by naive and memory CD4 cells during Ag-specific cognate interactions with APCs. We show that the mature immunological synapse forms more quickly during memory T cell activation. We further show that the composition of the synapse found in naive or memory cell conjugates with APCs is distinct with the tyrosine phosphatase, CD45, being a more integral component of the mature synapses formed by memory cells. Finally, we show that signaling molecules, including CD45, are preassociated in discrete, lipid-raft microdomains in resting memory cells but not in naive cells. Thus, enhanced memory cell responses may be due to intrinsic properties of signaling molecule organization.

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