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The Journal of Immunology, 2004, 173: 245-250.
Copyright © 2004 by The American Association of Immunologists

Reduction in the Developmental Potential of Intrathymic T Cell Progenitors with Age1

Hyeyoung Min, Encarnacion Montecino-Rodriguez and Kenneth Dorshkind2

Department of Pathology and Laboratory Medicine and Hematopoietic Malignancies Program Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095

Current models of thymic involution propose that intrinsic developmental defects in intrathymic T cell precursors do not contribute to age-related declines in thymopoiesis. This premise was reassessed in a murine model in light of the recent definition of the early T lineage progenitor (ETP), which appears to be the earliest intrathymic precursor defined to date. The results demonstrate that the frequency of ETP declines with age and their potential to reconstitute the thymus is diminished. These findings are consistent with the fact that ETP from aged mice proliferate less and have a higher rate of apoptosis than their counterparts from young animals. Taken together, these data suggest that age-associated changes in T cell precursors should be considered when attempts to rejuvenate the involuted thymus are made.


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