| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden;
Emory University School of Medicine, Department of Pathology, Atlanta, GA 30322;
Department of Pathology and Graduate Program in Immunology, University of Texas, Southwestern Medical Center, Dallas, TX 75390; and
Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nochtstrasse, Hamburg, Germany
Few studies have addressed the consequences of physical interactions between NK and T cells, as well as physical interactions among NK cells themselves. We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells. Furthermore, 2B4/CD48 interactions between NK cells also enhanced proliferation of NK cells in response to IL-2. Overall, these results suggest that NK cells augment the proliferation of neighboring T and NK cells through direct cell-cell contact. These results provide new insights into NK cell-mediated control of innate and adaptive immunity and demonstrate that receptor/ligand-specific cross talk between lymphocytes may occur in settings other than T-B cell or T-T cell interactions.
This article has been cited by other articles:
|
|
 |
|
  L. K. Chlewicki, C. A. Velikovsky, V. Balakrishnan, R. A. Mariuzza, and V. Kumar Molecular Basis of the Dual Functions of 2B4 (CD244) J. Immunol., June 15, 2008; 180(12): 8159 - 8167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kheradmand, P. P. Trivedi, N. A. Wolf, P. C. Roberts, and R. H. Swanborg Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats J. Leukoc. Biol., May 1, 2008; 83(5): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Han, Y. Fan, S. Wang, L. Jiao, H. Qiu, and X. Yang NK Cells Contribute to Intracellular Bacterial Infection-Mediated Inhibition of Allergic Responses J. Immunol., April 1, 2008; 180(7): 4621 - 4628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. T. Taniguchi, D. Guzior, and V. Kumar 2B4 inhibits NK-cell fratricide Blood, September 15, 2007; 110(6): 2020 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ralainirina, A. Poli, T. Michel, L. Poos, E. Andres, F. Hentges, and J. Zimmer Control of NK cell functions by CD4+CD25+ regulatory T cells J. Leukoc. Biol., January 1, 2007; 81(1): 144 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wendt, E. Wilk, S. Buyny, J. Buer, R. E. Schmidt, and R. Jacobs Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells J. Leukoc. Biol., December 1, 2006; 80(6): 1529 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Liu, L. V. Kaer, A. L. Cava, M. Price, D. I. Campagnolo, M. Collins, D. A. Young, T. L. Vollmer, and F.-D. Shi Autoreactive T Cells Mediate NK Cell Degeneration in Autoimmune Disease J. Immunol., May 1, 2006; 176(9): 5247 - 5254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Messmer, P. Eissmann, S. Stark, and C. Watzl CD48 Stimulation by 2B4 (CD244)-Expressing Targets Activates Human NK Cells. J. Immunol., April 15, 2006; 176(8): 4646 - 4650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Lee, J. P. Forman, M. E. McNerney, S. Stepp, S. Kuppireddi, D. Guzior, Y. E. Latchman, M. H. Sayegh, H. Yagita, C.-K. Park, et al. Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions Blood, April 15, 2006; 107(8): 3181 - 3188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bhat, P. Eissmann, J. Endt, S. Hoffmann, and C. Watzl Fine-tuning of immune responses by SLAM-related receptors J. Leukoc. Biol., March 1, 2006; 79(3): 417 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gao, P. Schwartzberg, J. A. Wilder, B. R. Blazar, and D. Yuan B Cell Induction of IL-13 Expression in NK Cells: Role of CD244 and SLAM-Associated Protein. J. Immunol., March 1, 2006; 176(5): 2758 - 2764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Stark and C. Watzl 2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells Int. Immunol., February 1, 2006; 18(2): 241 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Burgess, A. I. Marusina, I. Pathmanathan, F. Borrego, and J. E. Coligan IL-21 Down-Regulates NKG2D/DAP10 Expression on Human NK and CD8+ T Cells J. Immunol., February 1, 2006; 176(3): 1490 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Endsley, M. A. Endsley, and D. M. Estes Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages J. Leukoc. Biol., January 1, 2006; 79(1): 71 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Saborit-Villarroya, J. M. Del Valle, X. Romero, E. Esplugues, P. Lauzurica, P. Engel, and M. Martin The Adaptor Protein 3BP2 Binds Human CD244 and Links this Receptor to Vav Signaling, ERK Activation, and NK Cell Killing J. Immunol., October 1, 2005; 175(7): 4226 - 4235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Assarsson, T. Kambayashi, C. M. Persson, B. J. Chambers, and H.-G. Ljunggren 2B4/CD48-Mediated Regulation of Lymphocyte Activation and Function J. Immunol., August 15, 2005; 175(4): 2045 - 2049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. O. Mathew, P. R. Kumaresan, J. K. Lee, V. T. Huynh, and P. A. Mathew Mutational Analysis of the Human 2B4 (CD244)/CD48 Interaction: Lys68 and Glu70 in the V Domain of 2B4 Are Critical for CD48 Binding and Functional Activation of NK Cells J. Immunol., July 15, 2005; 175(2): 1005 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Trivedi, P. C. Roberts, N. A. Wolf, and R. H. Swanborg NK Cells Inhibit T Cell Proliferation via p21-Mediated Cell Cycle Arrest J. Immunol., April 15, 2005; 174(8): 4590 - 4597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Vaidya, S. E. Stepp, M. E. McNerney, J.-K. Lee, M. Bennett, K.-M. Lee, C. L. Stewart, V. Kumar, and P. A. Mathew Targeted Disruption of the 2B4 Gene in Mice Reveals an In Vivo Role of 2B4 (CD244) in the Rejection of B16 Melanoma Cells J. Immunol., January 15, 2005; 174(2): 800 - 807. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
