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BRIEF REVIEWS |
* Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; and
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama, Birmingham, AL 35294
Accumulating evidence indicates that positive selection events mediate differentiation, lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating the likelihood that newly formed cells will complete maturation, as well as whether cells persist within mature pools. Competition among B cells for limited, life span-promoting resources, which include self-ligands, lineage-specific cytokines, and innate receptor ligands, underlie these selective processes. Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process.
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