HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pobezinskaya, Y. Articles by Golovkina, T. V. Search for Related Content PubMed PubMed Citation Articles by Pobezinskaya, Y. Articles by Golovkina, T. V.

Initial Stages of Mammary Tumor Virus Infection Are Superantigen Independent¹

The Jackson Laboratory, Bar Harbor, ME 04609

Exogenous mouse mammary tumor virus (MMTV) is transmitted via the milk from infected mothers to newborn pups. Efficient MMTV transmission is dependent on proliferation of T cells with particular TCR -chains, which occurs upon recognition of virally encoded superantigen (SAg) bound to MHC class II molecules. It is assumed that infection of these dividing cells favors MMTV amplification. SAg is important for MMTV infection, as mice that lack SAg-cognate T cells due to expression of endogenous Mtv loci or mice that express inappropriate MHC haplotypes unable to present viral SAg efficiently were shown to be resistant to MMTV infection. However, this resistance was not absolute, as these mice developed late onset MMTV-induced mammary tumors. In this study, we show that the success of initial MMTV infection in neonates is independent of SAg function but depends on the developmentally regulated proliferation of target cells. However, SAg was absolutely required for virus spread following completion of this proliferative stage.

This article has been cited by other articles:

				C. M. Okeoma, M. Shen, and S. R. Ross A Novel Block to Mouse Mammary Tumor Virus Infection of Lymphocytes in B10.BR Mice J. Virol., February 1, 2008; 82(3): 1314 - 1322. [Abstract] [Full Text] [PDF]

				L. K. Case, L. Petell, L. Yurkovetskiy, A. Purdy, K. J. Savage, and T. V. Golovkina Replication of Beta- and Gammaretroviruses Is Restricted in I/LnJ Mice via the Same Genetic Mechanism J. Virol., February 1, 2008; 82(3): 1438 - 1447. [Abstract] [Full Text] [PDF]

				C. C. MacDearmid, L. K. Case, C. L. Starling, and T. V. Golovkina Gradual Elimination of Retroviruses in YBR/Ei Mice J. Virol., March 1, 2006; 80(5): 2206 - 2215. [Abstract] [Full Text] [PDF]