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CUTTING EDGE |
* Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104; and
Department of Inflammation Research, Amgen, Inc., Thousand Oaks, CA 91320
There are conflicting reports on the requirements for the IL-27-WSX-1 pathway in the development of Th type 1 responses and resistance to intracellular pathogens; although early IFN-
production and resistance to Leishmania major are impaired in the absence of WSX-1 signaling, WSX-1−/− mice generate robust IFN- responses and control infection with other intracellular protozoan pathogens. In this report, we resolve these conflicting observations and demonstrate that, in the absence of IL-4, WSX-1 is not required for early IFN- production and control of L. major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced.
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