| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
BRIEF REVIEWS |
* Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742; and
Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104
Upon stimulation, lymphocytes develop from small resting cells into highly proliferative and secretory cells. Although a great deal of study has focused on the genetic program induced by Ag receptor signals, lymphocytes must also regulate their metabolic function to meet the energetic demands of activation. In this review, we discuss the changes in cellular metabolism that accompany lymphocyte activation, with a particular emphasis on glucose metabolism, a major source of both energy and biosynthetic building blocks. We will also cover the signaling pathways that positively and negatively regulate these changes to maintain metabolic homeostasis in cells that are rapidly growing, dividing, and differentiating.
This article has been cited by other articles:
|
|
 |
|
  N. J. MacIver, S. R. Jacobs, H. L. Wieman, J. A. Wofford, J. L. Coloff, and J. C. Rathmell Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival J. Leukoc. Biol., October 1, 2008; 84(4): 949 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Tumeh, C. G. Radu, and A. Ribas PET Imaging of Cancer Immunotherapy J. Nucl. Med., June 1, 2008; 49(6): 865 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. Humphrey and S. G. Rudrappa Increased Glucose Availability Activates Chicken Thymocyte Metabolism and Survival J. Nutr., June 1, 2008; 138(6): 1153 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Jacobs, C. E. Herman, N. J. MacIver, J. A. Wofford, H. L. Wieman, J. J. Hammen, and J. C. Rathmell Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways J. Immunol., April 1, 2008; 180(7): 4476 - 4486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kiely, N. H McClenaghan, P. R Flatt, and P. Newsholme Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic {beta}-cell line J. Endocrinol., October 1, 2007; 195(1): 113 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Juntilla, J. A. Wofford, M. J. Birnbaum, J. C. Rathmell, and G. A. Koretzky Akt1 and Akt2 are required for {alpha}beta thymocyte survival and differentiation PNAS, July 17, 2007; 104(29): 12105 - 12110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Grigorian, S.-U. Lee, W. Tian, I.-J. Chen, G. Gao, R. Mendelsohn, J. W. Dennis, and M. Demetriou Control of T Cell-mediated Autoimmunity by Metabolite Flux to N-Glycan Biosynthesis J. Biol. Chem., July 6, 2007; 282(27): 20027 - 20035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, B. J. Altman, J. L. Coloff, C. E. Herman, S. R. Jacobs, H. L. Wieman, J. A. Wofford, L. N. Dimascio, O. Ilkayeva, A. Kelekar, et al. Glycogen Synthase Kinase 3{alpha} and 3{beta} Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1 Mol. Cell. Biol., June 15, 2007; 27(12): 4328 - 4339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fischer, P. Hoffmann, S. Voelkl, N. Meidenbauer, J. Ammer, M. Edinger, E. Gottfried, S. Schwarz, G. Rothe, S. Hoves, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells Blood, May 1, 2007; 109(9): 3812 - 3819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Wieman, J. A. Wofford, and J. C. Rathmell Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking Mol. Biol. Cell, April 1, 2007; 18(4): 1437 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Radu, C. J. Shu, S. M. Shelly, M. E. Phelps, and O. N. Witte Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis PNAS, February 6, 2007; 104(6): 1937 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. DeBerardinis, J. J. Lum, and C. B. Thompson Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth J. Biol. Chem., December 8, 2006; 281(49): 37372 - 37380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tamas, S. A. Hawley, R. G. Clarke, K. J. Mustard, K. Green, D. G. Hardie, and D. A. Cantrell Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes J. Exp. Med., July 10, 2006; 203(7): 1665 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Cham and T. F. Gajewski Glucose Availability Regulates IFN-{gamma} Production and p70S6 Kinase Activation in CD8+ Effector T Cells J. Immunol., April 15, 2005; 174(8): 4670 - 4677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Riley and C. H. June The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation Blood, January 1, 2005; 105(1): 13 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inobe and R. H. Schwartz CTLA-4 Engagement Acts as a Brake on CD4+ T Cell Proliferation and Cytokine Production but Is Not Required for Tuning T Cell Reactivity in Adaptive Tolerance J. Immunol., December 15, 2004; 173(12): 7239 - 7248. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
