| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121;
Department of Immunology, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan; and PRESTO, Japan Science and Technology Corporation, Honcho Kawaguchi, Saitama, Japan
The TNF receptor-associated factor (TRAF) family of molecules acts as adapter proteins for signaling pathways initiated by several members of the TNF receptor (TNFR) superfamily. TRAF5-/- animals are viable and have normal development of the immune system despite interacting with several TNFR family members. A clear role for TRAF5 has yet to emerge. OX40 (CD134) interacts with TRAF5, suggesting that this pathway could be involved in regulating T cell differentiation into Th1 or Th2 cells. In tissue culture, OX40 stimulation of TRAF5-/- T cells resulted in a pronounced Th2 phenotype with elevated levels of IL-4 and IL-5. Similarly, in vivo immunization with protein in adjuvant in the presence of an agonist anti-OX40 Ab resulted in enhanced Th2 development in TRAF5-/- mice. Additionally, lung inflammation induced by T cells, which is critically controlled by OX40, was more pronounced in TRAF5-/- mice, characterized by higher levels of Th2 cytokines. These results suggest that TRAF5 can limit the induction of Th2 responses, and that TRAF5 can play a role in modulating responses driven by OX40 costimulation.
This article has been cited by other articles:
|
|
 |
|
  Z. J. Kraus, J. S. Haring, and G. A. Bishop TNF Receptor-Associated Factor 5 Is Required for Optimal T Cell Expansion and Survival in Response to Infection J. Immunol., December 1, 2008; 181(11): 7800 - 7809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Potter, S. Eyre, A. Cope, J. Worthington, and A. Barton Investigation of association between the TRAF family genes and RA susceptibility Ann Rheum Dis, October 1, 2007; 66(10): 1322 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Esparza, T. Lindsten, J. M. Stockhausen, and R. H. Arch Tumor Necrosis Factor Receptor (TNFR)-associated Factor 5 Is a Critical Intermediate of Costimulatory Signaling Pathways Triggered by Glucocorticoid-induced TNFR in T Cells J. Biol. Chem., March 31, 2006; 281(13): 8559 - 8564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Bryce, M. K. Oyoshi, S. Kawamoto, H. C. Oettgen, and E. N. Tsitsikov TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45 Int. Immunol., January 1, 2006; 18(1): 101 - 111. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
