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Defining Th1 and Th2 Immune Responses in a Reciprocal Cytokine Environment In Vivo¹

Tanuja Chitnis^*, Alan D. Salama, Michael J. Grusby, Mohamed H. Sayegh and Samia J. Khoury^2,*

^* Center for Neurologic Diseases, Laboratory of Immunogenetics and Transplantation, Brigham and Women’s Hospital, and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115

The ability of committed Th1 and Th2 cells to function in altered cytokine environments is a central issue in autoimmune and immune-mediated diseases. Therefore, it is of interest to study the ability of Th1 or Th2 cells to expand and produce cytokine reciprocal environments in vivo. Using STAT4- and STAT6-deficient mice, we studied the expansion and cytokine production of Ag-specific Th1 or Th2 cells after transfer into Th1, Th2, or wild-type recipients. Our data show that these Th1 or Th2 cells proliferated and clonally expanded normally, regardless of the in vivo cytokine environment. These data have implications for the treatment of immune-mediated diseases by immunomodulatory agents that alter the cytokine milieu in vivo.