| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* First Department of Internal Medicine, Kansai Medical University, Osaka, Japan;
First Department of Pathology, Kansai Medical University, Osaka, Japan;
First Department of Internal Medicine, Kyoto University, Kyoto, Japan;
Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan; and
¶ Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Dendritic cells (DCs) show a functional plasticity in determining Th responses depending on their maturational stage or on maturational signals delivered to the DCs. Human plasmacytoid DCs (PDCs) can induce either Th1- or Th2-type immune responses upon exposure to viruses or IL-3, respectively. In this study we have investigated the Th-polarizing capacity of PDCs after short (24-h) or long (72-h) culture with stimuli and have assessed the expression and function of OX40 ligand (OX40L) in PDC-mediated Th polarization in addition to type I IFN-dependent responses. IL-3-treated PDCs expressed OX40L, but produced almost no IFN-
in response to T cell stimulation (CD40 ligand or T cell interaction), resulting in the preferential priming of Th2 cells through OX40L-dependent mechanisms. Meanwhile, PDCs were rapidly endowed by viral infection (Sendai virus) with a high potency to develop IFN-
-producing Th cells depending on their capacity to residually produce IFN-. Although Sendai virus-stimulated PDCs simultaneously expressed OX40L in their maturational process, the Th1-inducing effect of endogenous type I IFNs may overcome and thus conceal the OX40L-dependent Th2 responses. However, during maturation in response to Sendai virus over the longer 72-h period, the expression level of OX40L was up-regulated, whereas the residual IFN--producing ability was down-regulated, and consequently, the PDCs with prolonged Sendai virus stimulation induced Th2 responses to some extent. Thus, PDCs have the distinct means to dictate an appropriate response to environmental stimuli.
This article has been cited by other articles:
|
|
 |
|
  P. Bjorck, A. Beilhack, E. I. Herman, R. S. Negrin, and E. G. Engleman Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+ and CD8+ T Cell Activation In Vivo J. Immunol., September 15, 2008; 181(6): 3811 - 3817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, S. Liu, T. Zhang, W. Pan, X. Yang, and X. Cao Splenic Stromal Microenvironment Negatively Regulates Virus-Activated Plasmacytoid Dendritic Cells through TGF-{beta} J. Immunol., March 1, 2008; 180(5): 2951 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Veckman and I. Julkunen Streptococcus pyogenes activates human plasmacytoid and myeloid dendritic cells J. Leukoc. Biol., February 1, 2008; 83(2): 296 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takahashi, S. Satoi, H. Yanagimoto, N. Terakawa, H. Toyokawa, T. Yamamoto, Y. Matsui, S. Takai, A-H. Kwon, and Y. Kamiyama Circulating Dendritic Cells and Development of Septic Complications After Pancreatectomy for Pancreatic Cancer Arch Surg, December 1, 2007; 142(12): 1151 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ito, M. Yang, Y.-H. Wang, R. Lande, J. Gregorio, O. A Perng, X.-F. Qin, Y.-J. Liu, and M. Gilliet Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand J. Exp. Med., January 22, 2007; 204(1): 105 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kurooka and Y. Kaneda Inactivated Sendai Virus Particles Eradicate Tumors by Inducing Immune Responses through Blocking Regulatory T Cells Cancer Res., January 1, 2007; 67(1): 227 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Popovic, R. DeMarco, M. T. Lotze, S. E. Winikoff, D. L. Bartlett, A. M. Krieg, Z. S. Guo, C. K. Brown, K. J. Tracey, and H. J. Zeh III High Mobility Group B1 Protein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists J. Immunol., December 15, 2006; 177(12): 8701 - 8707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Allman, M. Dalod, C. Asselin-Paturel, T. Delale, S. H. Robbins, G. Trinchieri, C. A. Biron, P. Kastner, and S. Chan Ikaros is required for plasmacytoid dendritic cell differentiation Blood, December 15, 2006; 108(13): 4025 - 4034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Masten, G. K. Olson, C. A. Tarleton, C. Rund, M. Schuyler, R. Mehran, T. Archibeque, and M. F. Lipscomb Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung J. Immunol., December 1, 2006; 177(11): 7784 - 7793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kitawaki, N. Kadowaki, N. Sugimoto, N. Kambe, T. Hori, Y. Miyachi, T. Nakahata, and T. Uchiyama IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells Int. Immunol., December 1, 2006; 18(12): 1789 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Montoya, H.-B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells J. Immunol., July 15, 2006; 177(2): 1028 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mima, S. Yamamoto, M. Ito, R. Tomoshige, Y. Tabata, K. Tamai, and Y. Kaneda Targeted chemotherapy against intraperitoneally disseminated colon carcinoma using a cationized gelatin-conjugated HVJ envelope vector. Mol. Cancer Ther., April 1, 2006; 5(4): 1021 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Agostini, E. Cenci, E. Pericolini, G. Nocentini, G. Bistoni, A. Vecchiarelli, and C. Riccardi The Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related Gene Modulates the Response to Candida albicans Infection Infect. Immun., November 1, 2005; 73(11): 7502 - 7508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Bendriss-Vermare, S. Burg, H. Kanzler, L. Chaperot, T. Duhen, O. de Bouteiller, M. D'agostini, J.-M. Bridon, I. Durand, J. M. Sederstrom, et al. Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production J. Leukoc. Biol., October 1, 2005; 78(4): 954 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Morita, T. Uchiyama, and T. Hori Nitric Oxide Inhibits IFN-{alpha} Production of Human Plasmacytoid Dendritic Cells Partly via a Guanosine 3',5'-Cyclic Monophosphate-Dependent Pathway J. Immunol., July 15, 2005; 175(2): 806 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schlender, V. Hornung, S. Finke, M. Gunthner-Biller, S. Marozin, K. Brzozka, S. Moghim, S. Endres, G. Hartmann, and K.-K. Conzelmann Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus J. Virol., May 1, 2005; 79(9): 5507 - 5515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Marcenaro, M. D. Chiesa, F. Bellora, S. Parolini, R. Millo, L. Moretta, and A. Moretta IL-12 or IL-4 Prime Human NK Cells to Mediate Functionally Divergent Interactions with Dendritic Cells or Tumors J. Immunol., April 1, 2005; 174(7): 3992 - 3998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McKenna, A.-S. Beignon, and N. Bhardwaj Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity J. Virol., January 1, 2005; 79(1): 17 - 27. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
